PMID- 22754634
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 0976-5123 (Electronic)
IS  - 1995-705X (Print)
IS  - 1995-705X (Linking)
VI  - 13
IP  - 1
DP  - 2012 Jan
TI  - C-reactive Protein as a Predictor of Adverse outcome in Patients with Acute 
      Coronary Syndrome.
PG  - 7-12
LID - 10.4103/1995-705X.96660 [doi]
AB  - BACKGROUND AND OBJECTIVES: The acute-phase reactant C-reactive protein (CRP) has 
      been shown to reflect systemic and vascular inflammation and to predict future 
      cardiovascular events. The objective of this study was to evaluate the prognostic 
      value of CRP in predicting cardiovascular outcome in patients presenting with 
      acute coronary syndromes. PATIENTS AND METHODS: This prospective, single-centered 
      study was carried out by the Department of Pathology in collaboration with the 
      Department of Cardiology, Bolan Medical College Complex Quetta, Balochistan, 
      Pakistan from January 2009 to December 2009. We studied 963 consecutive patients 
      presenting with chest pain to Accident and Emergency Department. Patients were 
      divided into four groups. Group-1 comprised patients with unstable angina; 
      group-2 included patients with acute ST elevation myocardial infarction (STEMI); 
      group-3 comprised patients with Non-ST elevation myocardial infarction 
      (Non-STEMI) and group-4 was the control group. All four groups were followed-up 
      for 90 days for occurrence of cardiovascular events. RESULTS: The CRP was 
      elevated (>3 mg/L) among 27.6% patients in Group-1; 70.9% in group- 2; 77.9% in 
      group-3 and 5.3% in the control group. Among cases with elevated CRP, 92.1% had a 
      cardiac event compared to 34.3% among patients with CRP  pound3 mg/L (P < 0.0001). The 
      mortality was significantly higher (P < 0.0001) in group-2 (8.9%) and group-3 
      (11.9%) as compared to group-1 (2.1%). There was no cardiac event or mortality in 
      Group-4. CONCLUSIONS: Elevated CRP is a predictor of adverse outcome in patients 
      with acute coronary syndromes and helps in identifying patients who may be at 
      risk of cardiovascular complications.
FAU - Sheikh, A S
AU  - Sheikh AS
AD  - Department of Cardiology, Southend University Hospital NHS Foundation Trust, 
      Essex, UK.
FAU - Yahya, S
AU  - Yahya S
FAU - Sheikh, N S
AU  - Sheikh NS
FAU - Sheikh, A A
AU  - Sheikh AA
LA  - eng
PT  - Journal Article
PL  - India
TA  - Heart Views
JT  - Heart views : the official journal of the Gulf Heart Association
JID - 101316474
PMC - PMC3385197
OTO - NOTNLM
OT  - C-reactive protein
OT  - CRP
OT  - Cardiovascular disease
OT  - chest pain
OT  - coronary events
COIS- Conflict of Interest: None declared.
EDAT- 2012/07/04 06:00
MHDA- 2012/07/04 06:01
PMCR- 2012/01/01
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/07/04 06:01 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - HV-13-7 [pii]
AID - 10.4103/1995-705X.96660 [doi]
PST - ppublish
SO  - Heart Views. 2012 Jan;13(1):7-12. doi: 10.4103/1995-705X.96660.