PMID- 22754714
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2092-7363 (Electronic)
IS  - 2092-7355 (Print)
IS  - 2092-7355 (Linking)
VI  - 4
IP  - 4
DP  - 2012 Jul
TI  - Asian sand dust enhances allergen-induced th2 allergic inflammatory changes and 
      mucin production in BALB/c mouse lungs.
PG  - 206-13
LID - 10.4168/aair.2012.4.4.206 [doi]
AB  - PURPOSE: Recent studies have reported that Asian sand dust (ASD) has a potential 
      risk of aggravating airway inflammation. The purpose of this study was to 
      investigate the effect of ASD on inflammation and mucin production in the airways 
      of allergic mice. METHODS: FORTY BALB/C FEMALE MICE WERE DIVIDED INTO FOUR 
      GROUPS: saline (group 1); ASD (group 2); ovalbumin (OVA) alone (group 3); and 
      OVA+ASD (group 4). OVA-specific immunoglobulin E (IgE) in serum and interleukin 
      (IL)-4, IL-5, IL-13, and interferon-gamma (IFN-gamma) in bronchoalveolar lavage fluid 
      (BALF) were measured by enzyme-linked immunosorbent assay (ELISA). Hematoxylin & 
      eosin (H&E) and Periodic acid-Schiff (PAS) staining was performed on lung 
      tissues. In addition, immunohistochemical staining for IL-4, IL-5, MUC5AC, and 
      transforming growth factor alpha (TGF-alpha) was conducted. RESULTS: Serum IgE levels 
      were significantly higher in group 4 than in group 3 (P<0.05). IL-4 and IL-5 in 
      BALF were significantly higher in group 4 than in group 3 (P<0.05, respectively). 
      Based on H&E staining, inflammatory cell numbers were significantly greater in 
      group 4 than in the other groups (P<0.05). The number of PAS-positive cells was 
      also significantly greater in groups 3 and 4 than in groups 1 and 2 (P<0.05). The 
      numbers of IL-4 and IL-5-positive cells were higher in group 4 than in group 3 
      (P<0.05). The number of MUC5AC and TGF-alpha-positive cells were also higher in group 
      4 than in group 3 (P<0.05). CONCLUSIONS: Our data suggest that ASD increases 
      cytokine expression and mucin production in an allergic murine model. The 
      increased inflammatory reactions were related to cytokine production.
FAU - Kang, Il Gyu
AU  - Kang IG
AD  - Department of Otorhinolaryngology, Gil Hospital, Graduate School of Medicine, 
      Gachon University of Medicine and Science, Incheon, Korea.
FAU - Jung, Joo Hyun
AU  - Jung JH
FAU - Kim, Seon Tae
AU  - Kim ST
LA  - eng
PT  - Journal Article
DEP - 20120309
PL  - Korea (South)
TA  - Allergy Asthma Immunol Res
JT  - Allergy, asthma & immunology research
JID - 101518382
PMC - PMC3378927
OTO - NOTNLM
OT  - Asian sand dust
OT  - airway inflammation
OT  - mucin
COIS- There are no financial or other issues that might lead to conflict of interest.
EDAT- 2012/07/04 06:00
MHDA- 2012/07/04 06:01
PMCR- 2012/07/01
CRDT- 2012/07/04 06:00
PHST- 2011/09/29 00:00 [received]
PHST- 2011/11/11 00:00 [revised]
PHST- 2011/12/12 00:00 [accepted]
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/07/04 06:01 [medline]
PHST- 2012/07/01 00:00 [pmc-release]
AID - 10.4168/aair.2012.4.4.206 [doi]
PST - ppublish
SO  - Allergy Asthma Immunol Res. 2012 Jul;4(4):206-13. doi: 10.4168/aair.2012.4.4.206. 
      Epub 2012 Mar 9.