PMID- 22754762
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20210203
LR  - 20211021
IS  - 2162-4011 (Print)
IS  - 2162-402X (Electronic)
IS  - 2162-4011 (Linking)
VI  - 1
IP  - 4
DP  - 2012 Jul 1
TI  - Association of a functional Indoleamine 2,3-dioxygenase 2 genotype with specific 
      immune responses.
PG  - 441-447
AB  - Two frequent single-nucleotide-polymorphisms (SNPs) are present in the 
      indoleamine 2,3-dioxygenase 2 (IDO2) gene that influence its enzymatic activity. 
      Thus, one SNP (R248W) is associated with a reduction in IDO2 catalytic activity, 
      whereas the other SNP (Y359stop) generates a premature stop codon abolishing 
      activity completely. In the present study, we describe the presence of a specific 
      cellular immune response in the periphery which correlated with the functional 
      status of the IDO2 protein. Hence, the induction of IDO2-specific T cells in 
      peripheral blood requires the presence of a functional IDO2 protein and, 
      consequently, is restricted to individuals that are not homozygous for the stop 
      codon. Furthermore, we detected stronger T-cell responses in donors with the 
      homozygous Y wild type at position 359 when compared with the heterozygous 
      genotype. Interestingly, we found a higher number of immune responses against 
      IDO2 in patients homozygous for the 248W giving reduction in IDO2 activity 
      compared with the 248R. Hence, spontaneous immune responses against IDO2 seem to 
      be correlated with reduced enzymatic activity of IDO2. The patient IDO2 genotype 
      may well influence the outcome of IDO2-based anti-cancer vaccination.
FAU - Kollgaard, Tania
AU  - Kollgaard T
AD  - Center for Cancer Immune Therapy (CCIT); Department of Hematology; Copenhagen 
      University Hospital; Herlev, Denmark.
FAU - Klausen, Tobias Wirenfeldt
AU  - Klausen TW
FAU - Idorn, Manja
AU  - Idorn M
FAU - Holmgaard, Rikke Baek
AU  - Holmgaard RB
FAU - Straten, Per Thor
AU  - Straten PT
FAU - Andersen, Mads Hald
AU  - Andersen MH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Oncoimmunology
JT  - Oncoimmunology
JID - 101570526
PMC - PMC3382899
EDAT- 2012/07/04 06:00
MHDA- 2012/07/04 06:01
PMCR- 2012/07/01
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/07/04 06:01 [medline]
PHST- 2012/07/01 00:00 [pmc-release]
AID - 2011ONCOIMM0029R [pii]
AID - 19654 [pii]
AID - 10.4161/onci.19654 [doi]
PST - ppublish
SO  - Oncoimmunology. 2012 Jul 1;1(4):441-447. doi: 10.4161/onci.19654.