PMID- 22759780
OWN - NLM
STAT- MEDLINE
DCOM- 20121226
LR  - 20131121
IS  - 1473-5598 (Electronic)
IS  - 0263-6352 (Linking)
VI  - 30
IP  - 9
DP  - 2012 Sep
TI  - Persistent effect of early, brief angiotensin-converting enzyme inhibition on 
      segmental pressure dependency of aortic stiffness in spontaneously hypertensive 
      rats.
PG  - 1782-90
LID - 10.1097/HJH.0b013e3283562e35 [doi]
AB  - OBJECTIVE: The effect of brief, prehypertensive therapy by angiotensin-converting 
      enzyme inhibition (ACEi) with perindopril on the structure and function of large 
      arteries was studied in rats. METHODS: Spontaneously hypertensive rats (SHR) 
      received perindopril (3 mg/kg per day) between the ages of either 6 and 10 weeks 
      (early) or 20 and 24 weeks (late) and compared with nonmedicated SHR and 
      normotensive (Wistar-Kyoto) controls (n = 6 per group). Haemodynamic parameters 
      and segmental aortic stiffness assessed by pulse wave velocity (PWV) were 
      measured under urethane anaesthesia [1.3 g/kg, intraperitonealy (i.p.)] at 25 
      weeks. Aortic elastin and collagen content were determined by histomorphometry 
      and calcium content by atomic absorption spectrophotometry. RESULTS: Rats 
      receiving brief, early perindopril therapy had lower tail-cuff SBP than 
      nonmedicated SHR (121 +/- 1 mmHg, 179 +/- 5 mmHg, respectively, P < 0.05), reflected 
      in lower thoracic and abdominal aortic pulse pressures. Aortic pulse pressure 
      amplification was lower with early perindopril treatment (early treated 10 +/- 5%, 
      nonmedicated 20 +/- 10%, P < 0.05). No blood pressure (BP) differences were 
      observed between late treated and nonmedicated SHR. Isobaric thoracic PWV was 
      lower when treated early but not later in life. Treatment did not alter abdominal 
      PWV. Early treatment was associated with reduction in total aortic calcification 
      (48%, P < 0.001) and reduction in medial cross-sectional area (40%, P < 0.05) of 
      abdominal aorta compared with nonmedicated rats. Treatment increased the wall 
      thickness/diameter ratio, but only early treated rats had a 46% higher 
      elastin/collagen ratio compared with SHR controls. CONCLUSIONS: Early but not 
      late brief ACEi decreased arterial pressure and isobaric wall stiffness in SHR. 
      This was associated with marked alteration of wall structure and the effects 
      persisted after cessation of early treatment. The structural mechanisms 
      responsible for this change varied segmentally along the aortic trunk.
FAU - Ng, Keith
AU  - Ng K
AD  - Australian School of Advanced Medicine, Macquarie University, Sydney, Australia.
FAU - Butlin, Mark
AU  - Butlin M
FAU - Avolio, Alberto P
AU  - Avolio AP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Hypertens
JT  - Journal of hypertension
JID - 8306882
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - Y5GMK36KGY (Perindopril)
SB  - IM
MH  - Angiotensin-Converting Enzyme Inhibitors/*pharmacology
MH  - Animals
MH  - Aorta/*drug effects/physiopathology
MH  - Blood Pressure/drug effects
MH  - Heart Rate/drug effects
MH  - Hypertension/drug therapy
MH  - Male
MH  - Perindopril/therapeutic use
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - *Vascular Stiffness
EDAT- 2012/07/05 06:00
MHDA- 2012/12/27 06:00
CRDT- 2012/07/05 06:00
PHST- 2012/07/05 06:00 [entrez]
PHST- 2012/07/05 06:00 [pubmed]
PHST- 2012/12/27 06:00 [medline]
AID - 10.1097/HJH.0b013e3283562e35 [doi]
PST - ppublish
SO  - J Hypertens. 2012 Sep;30(9):1782-90. doi: 10.1097/HJH.0b013e3283562e35.