PMID- 22761741 OWN - NLM STAT- MEDLINE DCOM- 20130326 LR - 20211021 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 7 IP - 6 DP - 2012 TI - Plasma brain-derived neurotrophic factor levels predict the clinical outcome of depression treatment in a naturalistic study. PG - e39212 LID - 10.1371/journal.pone.0039212 [doi] LID - e39212 AB - Remission is the primary goal of treatment for major depressive disorder (MDD). However, some patients do not respond to treatment. The main purpose of this study was to determine whether brain-derived neurotrophic factor (BDNF) levels are correlated with treatment outcomes. In a naturalistic study, we assessed whether plasma BDNF levels were correlated with clinical outcomes by measuring plasma BDNF in patients with depressive syndrome (MADRS score >/= 18), and subsequently comparing levels between the subgroup of patients who underwent remission (MADRS score