PMID- 22763321
OWN - NLM
STAT- MEDLINE
DCOM- 20130215
LR  - 20211021
IS  - 1873-507X (Electronic)
IS  - 0031-9384 (Print)
IS  - 0031-9384 (Linking)
VI  - 107
IP  - 2
DP  - 2012 Sep 10
TI  - Estradiol selectively reduces central neural activation induced by hypertonic 
      NaCl infusion in ovariectomized rats.
PG  - 192-200
LID - S0031-9384(12)00239-9 [pii]
LID - 10.1016/j.physbeh.2012.06.015 [doi]
AB  - We recently reported that the latency to begin drinking water during slow, 
      intravenous infusion of a concentrated NaCl solution was shorter in 
      estradiol-treated ovariectomized rats compared to oil vehicle-treated rats, 
      despite comparably elevated plasma osmolality. To test the hypothesis that the 
      decreased latency to begin drinking is attributable to enhanced detection of 
      increased plasma osmolality by osmoreceptors located in the CNS, the present 
      study used immunocytochemical methods to label fos, a marker of neural 
      activation. Increased plasma osmolality did not activate the subfornical organ 
      (SFO), organum vasculosum of the lamina terminalis (OVLT), or the nucleus of the 
      solitary tract (NTS) in either oil vehicle-treated rats or estradiol-treated 
      rats. In contrast, hyperosmolality increased fos labeling in the area postrema 
      (AP), the paraventricular nucleus of the hypothalamus (PVN) and the rostral 
      ventrolateral medulla (RVLM) in both groups; however, the increase was blunted in 
      estradiol-treated rats. These results suggest that estradiol has selective 
      effects on the sensitivity of a population of osmo-/Na(+)-receptors located in 
      the AP, which, in turn, alters activity in other central areas associated with 
      responses to increased osmolality. In conjunction with previous reports that 
      hyperosmolality increases blood pressure and that elevated blood pressure 
      inhibits drinking, the current findings of reduced activation in AP, PVN, and 
      RVLM-areas involved in sympathetic nerve activity-raise the possibility that 
      estradiol blunts HS-induced blood pressure changes. Thus, estradiol may eliminate 
      or reduce the initial inhibition of water intake that occurs during increased 
      osmolality, and facilitate a more rapid behavioral response, as we observed in 
      our recent study.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Jones, Alexis B
AU  - Jones AB
AD  - Department of Pharmacology and Physiology, Oklahoma State University, Center for 
      Health Sciences, Tulsa, OK 74107-1898, USA.
FAU - Bass, Eryn E
AU  - Bass EE
FAU - Fan, Liming
AU  - Fan L
FAU - Curtis, Kathleen S
AU  - Curtis KS
LA  - eng
GR  - R03 DC006360/DC/NIDCD NIH HHS/United States
GR  - DC-06360/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120702
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Saline Solution, Hypertonic)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Animals
MH  - Area Postrema/drug effects/*physiology
MH  - Body Weight/drug effects
MH  - Estradiol/*pharmacology
MH  - Estrogen Replacement Therapy/methods
MH  - Female
MH  - Hypothalamus/drug effects/physiology
MH  - Infusions, Intravenous
MH  - Medulla Oblongata/drug effects/*physiology
MH  - Molecular Imaging/methods
MH  - Neural Pathways/drug effects/physiology
MH  - *Osmolar Concentration
MH  - Ovariectomy
MH  - Paraventricular Hypothalamic Nucleus/drug effects/*physiology
MH  - Plasma/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Saline Solution, Hypertonic/administration & dosage/*pharmacology
MH  - Solitary Nucleus/drug effects/physiology
MH  - Subfornical Organ/drug effects/physiology
PMC - PMC3590917
MID - NIHMS391165
EDAT- 2012/07/06 06:00
MHDA- 2013/02/16 06:00
PMCR- 2013/09/10
CRDT- 2012/07/06 06:00
PHST- 2012/03/22 00:00 [received]
PHST- 2012/06/16 00:00 [revised]
PHST- 2012/06/23 00:00 [accepted]
PHST- 2012/07/06 06:00 [entrez]
PHST- 2012/07/06 06:00 [pubmed]
PHST- 2013/02/16 06:00 [medline]
PHST- 2013/09/10 00:00 [pmc-release]
AID - S0031-9384(12)00239-9 [pii]
AID - 10.1016/j.physbeh.2012.06.015 [doi]
PST - ppublish
SO  - Physiol Behav. 2012 Sep 10;107(2):192-200. doi: 10.1016/j.physbeh.2012.06.015. 
      Epub 2012 Jul 2.