PMID- 22763425
OWN - NLM
STAT- MEDLINE
DCOM- 20130118
LR  - 20211021
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Print)
IS  - 0920-9964 (Linking)
VI  - 140
IP  - 1-3
DP  - 2012 Sep
TI  - Affect recognition in people at clinical high risk of psychosis.
PG  - 87-92
LID - 10.1016/j.schres.2012.06.012 [doi]
AB  - Individuals with schizophrenia demonstrate stable deficits in affect recognition. 
      Similar deficits in affect recognition have been observed in those who are at 
      clinical high risk (CHR) of developing psychosis. The current project aimed to 
      longitudinally examine affect processing in CHR individuals, to determine if 
      affect processing predicted later conversion to psychosis and if affect 
      processing deficits were unique to those who met established criteria for 
      prodromal syndromes. The sample consisted of 172 CHR and 100 help-seeking 
      individuals (HS) who were followed for up to 24 months. All CHR individuals met 
      the Criteria of Prodromal Syndromes (COPS) based on the Structured Interview for 
      Prodromal Symptoms (SIPS). The SIPS was used to determine conversion to 
      psychosis. Affect recognition was assessed using two facial affect recognition 
      tasks and a measure of affective prosody. In comparison to previously published 
      data from non-psychiatric controls, both CHR and HS groups demonstrated deficits 
      in affect recognition. By 2 years 25 CHR participants converted to psychosis. 
      Interestingly, there were no differences between converters and non-converters on 
      any affect recognition tasks. This is one of the first studies to longitudinally 
      examine affect processing and its relationship to later conversion to psychosis 
      in individuals at-risk for psychosis. While poorer affect recognition may be 
      associated with vulnerability for psychosis, the current results suggest that it 
      may not be a marker of developing a psychotic illness.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Addington, Jean
AU  - Addington J
AD  - Department of Psychiatry, Faculty of Medicine, University of Calgary, Calgary AB, 
      Canada. jmadding@ucalgary.ca
FAU - Piskulic, Danijela
AU  - Piskulic D
FAU - Perkins, Diana
AU  - Perkins D
FAU - Woods, Scott W
AU  - Woods SW
FAU - Liu, Lu
AU  - Liu L
FAU - Penn, David L
AU  - Penn DL
LA  - eng
GR  - U01 MH066069/MH/NIMH NIH HHS/United States
GR  - U01MH066069/MH/NIMH NIH HHS/United States
GR  - U01 MH066160/MH/NIMH NIH HHS/United States
GR  - U01MH066160/MH/NIMH NIH HHS/United States
GR  - U01 MH066134/MH/NIMH NIH HHS/United States
GR  - U01MH06634-02/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
DEP - 20120703
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Adolescent
MH  - *Affect
MH  - Cognition Disorders/*diagnosis/*etiology
MH  - Disease Progression
MH  - Early Diagnosis
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - *Prodromal Symptoms
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/*complications/diagnosis/*psychology
MH  - Risk Factors
MH  - Statistics, Nonparametric
MH  - Young Adult
PMC - PMC3460803
MID - NIHMS392680
COIS- Conflict of interest There are no conflicts of interest for any of the authors 
      with respect to the data in this paper or for the study.
EDAT- 2012/07/06 06:00
MHDA- 2013/01/19 06:00
PMCR- 2013/09/01
CRDT- 2012/07/06 06:00
PHST- 2012/02/04 00:00 [received]
PHST- 2012/06/05 00:00 [revised]
PHST- 2012/06/11 00:00 [accepted]
PHST- 2012/07/06 06:00 [entrez]
PHST- 2012/07/06 06:00 [pubmed]
PHST- 2013/01/19 06:00 [medline]
PHST- 2013/09/01 00:00 [pmc-release]
AID - S0920-9964(12)00329-5 [pii]
AID - 10.1016/j.schres.2012.06.012 [doi]
PST - ppublish
SO  - Schizophr Res. 2012 Sep;140(1-3):87-92. doi: 10.1016/j.schres.2012.06.012. Epub 
      2012 Jul 3.