PMID- 22763872
OWN - NLM
STAT- MEDLINE
DCOM- 20121106
LR  - 20170123
IS  - 1699-5848 (Electronic)
IS  - 0213-3911 (Linking)
VI  - 27
IP  - 8
DP  - 2012 Aug
TI  - Dendritic spines of the medial amygdala: plasticity, density, shape, and 
      subcellular modulation by sex steroids.
PG  - 985-1011
LID - 10.14670/HH-27.985 [doi]
AB  - The medial nucleus of the amygdala (MeA) is a complex component of the "extended 
      amygdala" in rats. Its posterodorsal subnucleus (MePD) has a remarkable 
      expression of gonadal hormone receptors, is sexually dimorphic or affected by sex 
      steroids, and modulates various social behaviors. Dendritic spines show 
      remarkable changes relevant for synaptic strength and plasticity. Adult males 
      have more spines than females, the density of dendritic spines changes in the 
      course of hours to a few days and is lower in proestrous and estrous phases of 
      the ovarian cycle, or is affected by both sex steroid withdrawal and hormonal 
      replacement therapy in the MePD. Males also have more thin spines than 
      mushroom-like or stubby/wide ones. The presence of dendritic fillopodia and 
      axonal protrusions in the MePD neuropil of adult animals reinforces the evidence 
      for local plasticity. Estrogen affects synaptic and cellular growth and 
      neuroprotection in the MeA by regulating the activity of the cyclic AMP response 
      element-binding protein (CREB)-related gene products, brain-derived neurotrophic 
      factor (BDNF), the anti-apoptotic protein B-cell lymphoma-2 (Bcl-2) and the 
      activity-regulated cytoskeleton-related protein (Arc). These effects on signal 
      transduction cascades can also lead to local protein synthesis and/or 
      rearrangement of the cytoskeleton and subsequent numerical/morphological 
      alterations in dendritic spines. Various working hypotheses are raised from these 
      experimental data and reveal the MePD as a relevant region to study the effects 
      of sex steroids in the rat brain.
FAU - Rasia-Filho, Alberto A
AU  - Rasia-Filho AA
AD  - Department of Basic Sciences/Physiology, Graduation Program in Pathology, Federal 
      University of Health Sciences of Porto Alegre, Brazil. rasiafilho@pq.cnpq.br
FAU - Dalpian, Francine
AU  - Dalpian F
FAU - Menezes, Itiana C
AU  - Menezes IC
FAU - Brusco, Janaina
AU  - Brusco J
FAU - Moreira, Jorge E
AU  - Moreira JE
FAU - Cohen, Rochelle S
AU  - Cohen RS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Spain
TA  - Histol Histopathol
JT  - Histology and histopathology
JID - 8609357
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (Gonadal Steroid Hormones)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (activity regulated cytoskeletal-associated protein)
SB  - IM
MH  - Amygdala/drug effects/*pathology
MH  - Animals
MH  - Axons/drug effects/pathology
MH  - Biomarkers/metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cell Proliferation/drug effects
MH  - Cyclic AMP Response Element-Binding Protein/metabolism
MH  - Cytoskeletal Proteins/metabolism
MH  - Cytoskeleton/drug effects/ultrastructure
MH  - Dendritic Spines/drug effects/*pathology/ultrastructure
MH  - Estrous Cycle
MH  - Female
MH  - Gonadal Steroid Hormones/*pharmacology
MH  - Male
MH  - Nerve Tissue Proteins/metabolism
MH  - Neurons/drug effects/*pathology
MH  - Neuropil/drug effects/pathology
MH  - Proto-Oncogene Proteins c-bcl-2/metabolism
MH  - Rats
MH  - Sex Factors
MH  - Signal Transduction
EDAT- 2012/07/06 06:00
MHDA- 2012/11/07 06:00
CRDT- 2012/07/06 06:00
PHST- 2012/07/06 06:00 [entrez]
PHST- 2012/07/06 06:00 [pubmed]
PHST- 2012/11/07 06:00 [medline]
AID - 10.14670/HH-27.985 [doi]
PST - ppublish
SO  - Histol Histopathol. 2012 Aug;27(8):985-1011. doi: 10.14670/HH-27.985.