PMID- 22766099
OWN - NLM
STAT- MEDLINE
DCOM- 20121211
LR  - 20120914
IS  - 1879-0089 (Electronic)
IS  - 0145-305X (Linking)
VI  - 38
IP  - 2
DP  - 2012 Oct
TI  - The ontogeny of New Zealand groper (Polyprion oxygeneios) lymphoid organs and 
      IgM.
PG  - 215-23
LID - S0145-305X(12)00135-8 [pii]
LID - 10.1016/j.dci.2012.06.007 [doi]
AB  - This study investigates the ontogeny of New Zealand groper (Polyprion oxygeneios) 
      immune system, a new species for aquaculture in the Southern Pacific Ocean. In 
      the eggs, both lysozyme and IgM were detected. Egg IgM was found at 1.07-1.56 
      mug/g wet weight and consisted of monomers compared to the polymerized IgM found 
      in adult serum. In larvae, the head-kidney (HK) was first observed at 6 dph, 
      followed by the spleen at 16 dph, and thymus at 20 dph, and within these organs 
      IgM(+) cells were first detected in the HK (12 dph), then the spleen (32 dph) and 
      finally in the thymus and the gastrointestinal tract (45 dph). Low levels of Igmu 
      heavy chain transcripts were detected at 2 and 3 dph and they increased at 9 dph. 
      Igmu expression further increased from day 45 onwards. In juveniles (115 dph), the 
      HK and blood showed similar percentages of IgM(+) cells as the adult groper. 
      These results highlight the important maturation steps that occur during the 
      development of the immune system in the marine teleost P. oxygeneios.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Parker, S
AU  - Parker S
AD  - School of Biological Sciences, Victoria University of Wellington, Wellington, New 
      Zealand.
FAU - La Flamme, A
AU  - La Flamme A
FAU - Salinas, I
AU  - Salinas I
LA  - eng
PT  - Journal Article
DEP - 20120702
PL  - United States
TA  - Dev Comp Immunol
JT  - Developmental and comparative immunology
JID - 7708205
RN  - 0 (Immunoglobulin M)
RN  - EC 3.2.1.17 (Muramidase)
SB  - IM
MH  - Animals
MH  - Head Kidney/cytology/embryology
MH  - Immunoglobulin M/analysis/immunology
MH  - Lymphoid Tissue/cytology/*embryology
MH  - Muramidase/analysis/metabolism
MH  - Perciformes/*embryology/*immunology
EDAT- 2012/07/07 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/07/07 06:00
PHST- 2011/11/27 00:00 [received]
PHST- 2012/06/18 00:00 [revised]
PHST- 2012/06/23 00:00 [accepted]
PHST- 2012/07/07 06:00 [entrez]
PHST- 2012/07/07 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - S0145-305X(12)00135-8 [pii]
AID - 10.1016/j.dci.2012.06.007 [doi]
PST - ppublish
SO  - Dev Comp Immunol. 2012 Oct;38(2):215-23. doi: 10.1016/j.dci.2012.06.007. Epub 
      2012 Jul 2.