PMID- 22766130
OWN - NLM
STAT- MEDLINE
DCOM- 20130118
LR  - 20211021
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Print)
IS  - 0920-9964 (Linking)
VI  - 140
IP  - 1-3
DP  - 2012 Sep
TI  - BDNF Val66Met and spontaneous dyskinesias in non-clinical psychosis.
PG  - 65-70
LID - 10.1016/j.schres.2012.06.018 [doi]
AB  - BACKGROUND: Evidence indicating that symptoms of non-clinical psychosis (NCP) 
      occur in 6-8% of the general population suggests that psychosis may occur across 
      a continuum. Although a number of studies have examined environmental 
      contributors, to date there have been few investigations of biological/genetic 
      factors in this integral population. A recent study observed spontaneous 
      dyskinetic movements (reflecting an innervated striatal system) in individuals 
      reporting NCP. The present investigation is designed to replicate this finding 
      and determine if brain-derived neurotrophic factor (BDNF) (implicated in striatal 
      dopamine function) is associated with dyskinesias. METHOD: A total of 68 
      young-adult participants reporting High and Low-NCP were assessed for dyskinetic 
      movements using a sensitive instrumental measure of force variability. Saliva 
      from the participants was genotyped for val66met (rs6265), a common functional 
      polymorphism of the BDNF gene (the Met allele is associated with lower 
      activity-dependent release of BDNF). RESULTS: Participants in the High-NCP group 
      showed significantly elevated levels of force variability. Met allele carriers 
      exhibited significantly higher levels of force variability when compared with the 
      Val homozygotes. Logistic regression indicated that the odds of membership in the 
      High-NCP group were significantly higher given the presence of dyskinesias 
      (OR=2.32; CI: 1.25-4.28). CONCLUSION: Findings of elevated force variability 
      suggest that individuals with NCP exhibit subtle signs of striatal vulnerability, 
      reflected more dramatically as jerking and hyperkinetic movements in patients 
      with formal psychosis. The results are consistent with a larger literature 
      implicating BDNF as a critical factor underlying abnormal movements, and suggest 
      that specific candidate genes underlie putative markers across a psychosis 
      continuum.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Mittal, Vijay A
AU  - Mittal VA
AD  - Department of Psychology and Neuroscience, University of Colorado Boulder, 345 
      UCB, Boulder, CO 80309-0345, USA. vijay.mittal@colorado.edu
FAU - Smolen, Andrew
AU  - Smolen A
FAU - Dean, Derek J
AU  - Dean DJ
FAU - Pelletier, Andrea L
AU  - Pelletier AL
FAU - Lunsford-Avery, Jessica
AU  - Lunsford-Avery J
FAU - Smith, Ashley
AU  - Smith A
LA  - eng
GR  - L30 MH087258/MH/NIMH NIH HHS/United States
GR  - R01 MH094650/MH/NIMH NIH HHS/United States
GR  - MH087258/MH/NIMH NIH HHS/United States
GR  - R01MH094650/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120704
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Analysis of Variance
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - DNA Mutational Analysis
MH  - Dyskinesias/*etiology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Methionine/*genetics
MH  - Neuropsychological Tests
MH  - *Polymorphism, Single Nucleotide
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/*complications/*genetics
MH  - Valine/*genetics
MH  - Young Adult
PMC - PMC3423560
MID - NIHMS388691
COIS- Conflict of Interest There are no conflicts of interest to report.
EDAT- 2012/07/07 06:00
MHDA- 2013/01/19 06:00
PMCR- 2013/09/01
CRDT- 2012/07/07 06:00
PHST- 2012/04/25 00:00 [received]
PHST- 2012/06/10 00:00 [revised]
PHST- 2012/06/13 00:00 [accepted]
PHST- 2012/07/07 06:00 [entrez]
PHST- 2012/07/07 06:00 [pubmed]
PHST- 2013/01/19 06:00 [medline]
PHST- 2013/09/01 00:00 [pmc-release]
AID - S0920-9964(12)00335-0 [pii]
AID - 10.1016/j.schres.2012.06.018 [doi]
PST - ppublish
SO  - Schizophr Res. 2012 Sep;140(1-3):65-70. doi: 10.1016/j.schres.2012.06.018. Epub 
      2012 Jul 4.