PMID- 22766373
OWN - NLM
STAT- MEDLINE
DCOM- 20130201
LR  - 20220408
IS  - 1096-0023 (Electronic)
IS  - 1043-4666 (Print)
IS  - 1043-4666 (Linking)
VI  - 60
IP  - 1
DP  - 2012 Oct
TI  - Monocyte Chemoattractant Protein 1 (MCP-1) in obesity and diabetes.
PG  - 1-12
LID - 10.1016/j.cyto.2012.06.018 [doi]
AB  - Monocyte Chemoattractant Protein-1 (MCP-1) is the first discovered and most 
      extensively studied CC chemokine, and the amount of studies on its role in the 
      etiologies of obesity- and diabetes-related diseases have increased exponentially 
      during the past two decades. This review attempted to provide a panoramic 
      perspective of the history, regulatory mechanisms, functions, and therapeutic 
      strategies of this chemokine. The highlights of this review include the roles of 
      MCP-1 in the development of obesity, diabetes, cardiovascular diseases, 
      insulitis, diabetic nephropathy, and diabetic retinopathy. Therapies that 
      specifically or non-specifically inhibit MCP-1 overproduction have been 
      summarized.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Panee, Jun
AU  - Panee J
AD  - Department of Cell and Molecular Biology, John A. Burns School of Medicine, 
      University of Hawaii, 651 Ilalo Street BSB 222, Honolulu, HI 96813, USA. 
      junchen@hawaii.edu
LA  - eng
GR  - 5P20RR016467/RR/NCRR NIH HHS/United States
GR  - U54RR022762/RR/NCRR NIH HHS/United States
GR  - R21 AT003874/AT/NCCIH NIH HHS/United States
GR  - 5G12RR003061/RR/NCRR NIH HHS/United States
GR  - U54 MD007584/MD/NIMHD NIH HHS/United States
GR  - R21 AT005139/AT/NCCIH NIH HHS/United States
GR  - P20 RR016467/RR/NCRR NIH HHS/United States
GR  - G12 RR003061/RR/NCRR NIH HHS/United States
GR  - U54 MD008149/MD/NIMHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20120704
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Animals
MH  - Cardiovascular Diseases/metabolism/*physiopathology/prevention & control
MH  - Chemokine CCL2/antagonists & inhibitors/metabolism/*physiology
MH  - Diabetes Complications/metabolism/*physiopathology/prevention & control
MH  - Diabetes Mellitus, Type 2/metabolism/*physiopathology/prevention & control
MH  - Drug Therapy/methods
MH  - Humans
MH  - Obesity/metabolism/*physiopathology/prevention & control
MH  - Signal Transduction/drug effects
PMC - PMC3437929
MID - NIHMS392719
EDAT- 2012/07/07 06:00
MHDA- 2013/02/05 06:00
PMCR- 2013/10/01
CRDT- 2012/07/07 06:00
PHST- 2011/12/14 00:00 [received]
PHST- 2012/05/30 00:00 [revised]
PHST- 2012/06/04 00:00 [accepted]
PHST- 2012/07/07 06:00 [entrez]
PHST- 2012/07/07 06:00 [pubmed]
PHST- 2013/02/05 06:00 [medline]
PHST- 2013/10/01 00:00 [pmc-release]
AID - S1043-4666(12)00264-5 [pii]
AID - 10.1016/j.cyto.2012.06.018 [doi]
PST - ppublish
SO  - Cytokine. 2012 Oct;60(1):1-12. doi: 10.1016/j.cyto.2012.06.018. Epub 2012 Jul 4.