PMID- 22766400
OWN - NLM
STAT- MEDLINE
DCOM- 20121017
LR  - 20181201
IS  - 1879-0038 (Electronic)
IS  - 0378-1119 (Linking)
VI  - 506
IP  - 2
DP  - 2012 Sep 15
TI  - MDR1 single nucleotide polymorphism C3435T in Turkish patients with 
      non-small-cell lung cancer.
PG  - 404-7
LID - 10.1016/j.gene.2012.06.057 [doi]
AB  - We assessed whether single nucleotide polymorphisms (SNPs) in MDR1 gene C3435T 
      predicted the outcome of platinum-based chemotherapies and survival in our non 
      small cell lung cancer (NSCLC) patients. A total of 79 non-small cell lung cancer 
      patients were enrolled to study. We determined the MDR1 C3435T single nucleotide 
      gene polymorphisms. Median age was 60years: 91.7% male, 8.9% female. We found 
      that CC, CT, TT genotype and T, C allele frequencies in lung cancer patients as 
      24.1%, 62%, 13.9% and 44.3%, 55.7%, respectively. Patients with CT genotype had a 
      higher response rate (11.4%) than the other genotypes. However, this difference 
      is not statistically significant (p=0.743). Cox regression analysis for overall 
      survival showed that ECOG PS status 0 (HR PS 1 vs. 0, 5.68 p=0.002; HR of PS 2 
      vs. 0 is 21.579, p=0.001; HR of PS 3 vs. 0 is 35.35, p=0.001), stage </=II (HR of 
      stage III vs. I+II is 17.77; p=0.016, HR of stage IV vs. I+II is 26.97, p=0.006), 
      and albumin level >/=3g/dl (HR of albumin <3g/dl vs. >/=3g/dl is 2.46, p=0.044) were 
      the most important prognostic factors (also, time to progression was related to 
      these factors). There was no significant association between the genotypes and 
      clinicopathologic parameters; however, good performance status, early stage and 
      >/=3g/dl albumin level were found to be the most important prognostic factors for 
      overall survival and progression-free survival.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Dogu, Gamze Gokoz
AU  - Dogu GG
AD  - Department of Internal Medicine, Division of Medical Oncology, Faculty of 
      Medicine, University of Pamukkale, Denizli, Turkey.
FAU - Kargi, Aysegul
AU  - Kargi A
FAU - Turgut, Sebahat
AU  - Turgut S
FAU - Ayada, Ceylan
AU  - Ayada C
FAU - Taskoylu, Burcu Yapar
AU  - Taskoylu BY
FAU - Demiray, Gokcen
AU  - Demiray G
FAU - Yaren, Arzu
AU  - Yaren A
FAU - Ozlu, Can
AU  - Ozlu C
FAU - Temel, Sahin
AU  - Temel S
FAU - Ergin, Ahmet
AU  - Ergin A
LA  - eng
PT  - Journal Article
DEP - 20120702
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (ABCB1 protein, human)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 1)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily B
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 1/*genetics
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Non-Small-Cell Lung/ethnology/*genetics
MH  - Disease-Free Survival
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Lung Neoplasms/ethnology/*genetics
MH  - Male
MH  - Middle Aged
MH  - Models, Genetic
MH  - *Polymorphism, Single Nucleotide
MH  - Regression Analysis
MH  - Turkey
EDAT- 2012/07/07 06:00
MHDA- 2012/10/18 06:00
CRDT- 2012/07/07 06:00
PHST- 2012/06/08 00:00 [received]
PHST- 2012/06/19 00:00 [accepted]
PHST- 2012/07/07 06:00 [entrez]
PHST- 2012/07/07 06:00 [pubmed]
PHST- 2012/10/18 06:00 [medline]
AID - S0378-1119(12)00767-6 [pii]
AID - 10.1016/j.gene.2012.06.057 [doi]
PST - ppublish
SO  - Gene. 2012 Sep 15;506(2):404-7. doi: 10.1016/j.gene.2012.06.057. Epub 2012 Jul 2.