PMID- 22767247
OWN - NLM
STAT- MEDLINE
DCOM- 20130417
LR  - 20240204
IS  - 0219-1032 (Electronic)
IS  - 1016-8478 (Print)
IS  - 1016-8478 (Linking)
VI  - 34
IP  - 3
DP  - 2012 Sep
TI  - The bloodline of CD8alpha(+) dendritic cells.
PG  - 219-29
AB  - The immune system is highly coordinated by various cell types. Dendritic cells 
      (DCs) orchestrate immune responses at various stages and bridge innate immunity 
      and adaptive immunity. DCs are a family of cells consisting of various subsets 
      distinguished by surface markers, locations, and transcription factors that 
      govern their development, differentiation, and homeostasis. The complexity of DC 
      subset biology has hindered the understanding of the functional differences among 
      DC subsets. The subset expressing the surface molecule CD8alpha is of particular 
      interest, due to the efficiency of this DC subset in priming CD8(+) cytotoxic T 
      cells and cross-presenting exogenous antigens to CD8(+) T cells. CD8alpha(+) DCs 
      maintain tolerance to autologous antigens at steady state, but when activated 
      secrete IL-12, polarizing T helper (Th) 1 responses. Recently, novel DC subsets 
      were found to be present in peripheral tissues and the relationship between 
      CD8alpha(+) DCs in lymphoid organs and DC subsets in peripheral tissues has been 
      revealed. This review describes the pedigree of CD8alpha(+) DCs and related subsets, 
      including a history of the discovery of DC subsets and their functional 
      characterization.
FAU - Kang, Suk-Jo
AU  - Kang SJ
AD  - Department of Biological Sciences, Korea Advanced Institute of Science and 
      Technology, Daejeon, 305-701, Korea. suk-jo.kang@kaist.ac.kr
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120704
PL  - United States
TA  - Mol Cells
JT  - Molecules and cells
JID - 9610936
RN  - 0 (Antigens, CD)
RN  - 0 (CD207 protein, human)
RN  - 0 (CD8 Antigens)
RN  - 0 (CD8 antigen, alpha chain)
RN  - 0 (Integrin alpha Chains)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Mannose-Binding Lectins)
RN  - 0 (alpha E integrins)
RN  - 187348-17-0 (Interleukin-12)
SB  - IM
MH  - Animals
MH  - Antigens, CD/immunology/metabolism
MH  - CD8 Antigens/*immunology/*metabolism
MH  - CD8-Positive T-Lymphocytes/immunology/metabolism
MH  - Dendritic Cells/cytology/*physiology
MH  - Humans
MH  - Integrin alpha Chains/immunology/metabolism
MH  - Interleukin-12/metabolism
MH  - Lectins, C-Type/immunology/metabolism
MH  - Mannose-Binding Lectins/immunology/metabolism
MH  - Mice
MH  - Th1 Cells/immunology
PMC - PMC3887845
EDAT- 2012/07/07 06:00
MHDA- 2013/04/18 06:00
PMCR- 2013/09/30
CRDT- 2012/07/07 06:00
PHST- 2012/02/22 00:00 [received]
PHST- 2012/05/25 00:00 [accepted]
PHST- 2012/05/24 00:00 [revised]
PHST- 2012/07/07 06:00 [entrez]
PHST- 2012/07/07 06:00 [pubmed]
PHST- 2013/04/18 06:00 [medline]
PHST- 2013/09/30 00:00 [pmc-release]
AID - S1016-8478(23)07027-9 [pii]
AID - molcell-34-3-219-1 [pii]
AID - 10.1007/s10059-012-0058-6 [doi]
PST - ppublish
SO  - Mol Cells. 2012 Sep;34(3):219-29. doi: 10.1007/s10059-012-0058-6. Epub 2012 Jul 
      4.