PMID- 22768299
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20240317
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 7
DP  - 2012
TI  - Plasma BDNF levels vary in relation to body weight in females.
PG  - e39358
LID - 10.1371/journal.pone.0039358 [doi]
LID - e39358
AB  - Brain derived neurotrophic factor (BDNF) has been implicated in the 
      pathophysiology of depression as well as neuropsychiatric and neurodegenerative 
      disorders. Recent studies show a role of BDNF in energy metabolism and body 
      weight regulation. We examined BDNF levels in plasma and cerebrospinal fluid 
      (CSF) samples from age matched elderly depressed and control subjects. Also, the 
      association of BDNF levels with age, gender, body weight, body mass index (BMI), 
      and cognitive performance was evaluated. We did not find any significant 
      differences in plasma and CSF BDNF levels between depressed and control subjects. 
      Plasma BDNF levels were negatively correlated with age (but not with BMI and body 
      weight), when analyses were performed including both depressed and control 
      subjects. A significant reduction in plasma BDNF levels was observed in females 
      as compared to male subjects, and the change in BDNF levels were significantly 
      and positively related to body weight in females. Furthermore, significant 
      increases in Total Recall and Delayed Recall values were found in females as 
      compared to males. In conclusion, the lower BDNF levels observed in females 
      suggest that changes in peripheral BDNF levels are likely secondary to an altered 
      energy balance. However, further studies using larger sample size are warranted.
FAU - Pillai, Anilkumar
AU  - Pillai A
AD  - Department of Psychiatry and Health Behavior, Medical College of Georgia, Georgia 
      Health Sciences University, Augusta, Georgia, USA. apillai@georgiahealth.edu
FAU - Bruno, Davide
AU  - Bruno D
FAU - Sarreal, Antero S
AU  - Sarreal AS
FAU - Hernando, Raymundo T
AU  - Hernando RT
FAU - Saint-Louis, Leslie A
AU  - Saint-Louis LA
FAU - Nierenberg, Jay
AU  - Nierenberg J
FAU - Ginsberg, Stephen D
AU  - Ginsberg SD
FAU - Pomara, Nunzio
AU  - Pomara N
FAU - Mehta, Pankaj D
AU  - Mehta PD
FAU - Zetterberg, Henrik
AU  - Zetterberg H
FAU - Blennow, Kaj
AU  - Blennow K
FAU - Buckley, Peter F
AU  - Buckley PF
LA  - eng
GR  - R01 AG043375/AG/NIA NIH HHS/United States
GR  - P01 AG014449/AG/NIA NIH HHS/United States
GR  - P01 AG017617/AG/NIA NIH HHS/United States
GR  - P50 MH086385/MH/NIMH NIH HHS/United States
GR  - F31 MH080505/MH/NIMH NIH HHS/United States
GR  - R01 MH-080505/MH/NIMH NIH HHS/United States
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
DEP - 20120702
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Aged
MH  - Body Weight/*physiology
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Energy Metabolism/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Sex Characteristics
PMC - PMC3388065
COIS- Competing Interests: Co-author Stephen D. Ginsberg is a PLoS ONE Editorial Board 
      member. This does not alter the authors' adherence to all the PLoS ONE policies 
      on sharing data and materials.
EDAT- 2012/07/07 06:00
MHDA- 2012/11/14 06:00
PMCR- 2012/07/02
CRDT- 2012/07/07 06:00
PHST- 2012/03/23 00:00 [received]
PHST- 2012/05/21 00:00 [accepted]
PHST- 2012/07/07 06:00 [entrez]
PHST- 2012/07/07 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
PHST- 2012/07/02 00:00 [pmc-release]
AID - PONE-D-12-08518 [pii]
AID - 10.1371/journal.pone.0039358 [doi]
PST - ppublish
SO  - PLoS One. 2012;7(7):e39358. doi: 10.1371/journal.pone.0039358. Epub 2012 Jul 2.