PMID- 22768323
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20221207
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 7
DP  - 2012
TI  - Dysregulation of cytokine response in Canadian First Nations communities: is 
      there an association with persistent organic pollutant levels?
PG  - e39931
LID - 10.1371/journal.pone.0039931 [doi]
LID - e39931
AB  - In vitro and animal studies report that some persistent organic pollutants (POPs) 
      trigger the secretion of proinflammatory cytokines. Whether POP exposure is 
      associated with a dysregulation of cytokine response remains to be investigated 
      in humans. We studied the strength of association between plasma POP levels and 
      circulating cytokines as immune activation markers. Plasma levels of fourteen 
      POPs and thirteen cytokines were measured in 39 Caucasians from a comparator 
      sample in Quebec City (Canada) and 72 First Nations individuals from two northern 
      communities of Ontario (Canada). Caucasians showed significantly higher levels of 
      organochlorine insecticides (beta-HCH, p,p'-DDE and HCB) compared to First Nations. 
      Conversely, First Nations showed higher levels of Mirex, Aroclor 1260, PCB 153, 
      PCB 170, PCB 180 and PCB 187 compared to Caucasians. While there was no 
      difference in cytokine levels of IL-4, IL-6, IL-10 and IL-22 between groups, 
      First Nations had significantly greater average levels of IFNgamma, IL-1beta, IL-2, 
      IL-5, IL-8, IL-12p70, IL-17A, TNFalpha and TNFbeta levels compared to Caucasians. Among 
      candidate predictor variables (age, body mass index, insulin resistance and POP 
      levels), high levels of PCBs were the only predictor accounting for a small but 
      significant effect of observed variance ( approximately 7%) in cytokine levels. Overall, a weak 
      but significant association is detected between persistent organochlorine 
      pollutant exposure and elevated cytokine levels. This finding augments the 
      already existing information that environmental pollution is related to 
      inflammation, a common feature of several metabolic disorders that are known to 
      be especially prevalent in Canada's remote First Nations communities.
FAU - Imbeault, Pascal
AU  - Imbeault P
AD  - Behavioral and Metabolic Research Unit, School of Human Kinetics, Faculty of 
      Health Sciences, University of Ottawa, Ottawa, Ontario, Canada. 
      imbeault@uottawa.ca
FAU - Findlay, C Scott
AU  - Findlay CS
FAU - Robidoux, Michael A
AU  - Robidoux MA
FAU - Haman, Francois
AU  - Haman F
FAU - Blais, Jules M
AU  - Blais JM
FAU - Tremblay, Angelo
AU  - Tremblay A
FAU - Springthorpe, Susan
AU  - Springthorpe S
FAU - Pal, Shinjini
AU  - Pal S
FAU - Seabert, Tim
AU  - Seabert T
FAU - Krummel, Eva M
AU  - Krummel EM
FAU - Maal-Bared, Rasha
AU  - Maal-Bared R
FAU - Tetro, Jason A
AU  - Tetro JA
FAU - Pandey, Sunita
AU  - Pandey S
FAU - Sattar, Syed A
AU  - Sattar SA
FAU - Filion, Lionel G
AU  - Filion LG
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20120702
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Cytokines)
RN  - 0 (Hazardous Substances)
RN  - 0 (Insecticides)
SB  - IM
MH  - Adult
MH  - Cytokines/*blood
MH  - Environmental Exposure/*adverse effects
MH  - Female
MH  - Hazardous Substances/*adverse effects
MH  - Humans
MH  - Inflammation/blood/chemically induced
MH  - Insecticides/*adverse effects
MH  - Male
MH  - Metabolic Diseases/*blood/chemically induced/epidemiology
MH  - Middle Aged
MH  - Ontario/epidemiology
MH  - White People
PMC - PMC3388062
COIS- Competing Interests: The authors have the following conflicts: Co-author Lionel 
      G. Filion is a PLoS ONE Editorial Board member. This does not alter the authors' 
      adherence to all the PLoS ONE policies on sharing data and materials.
EDAT- 2012/07/07 06:00
MHDA- 2012/11/14 06:00
PMCR- 2012/07/02
CRDT- 2012/07/07 06:00
PHST- 2012/04/16 00:00 [received]
PHST- 2012/05/29 00:00 [accepted]
PHST- 2012/07/07 06:00 [entrez]
PHST- 2012/07/07 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
PHST- 2012/07/02 00:00 [pmc-release]
AID - PONE-D-12-12162 [pii]
AID - 10.1371/journal.pone.0039931 [doi]
PST - ppublish
SO  - PLoS One. 2012;7(7):e39931. doi: 10.1371/journal.pone.0039931. Epub 2012 Jul 2.