PMID- 22768775
OWN - NLM
STAT- MEDLINE
DCOM- 20150615
LR  - 20181201
IS  - 1000-1182 (Print)
IS  - 1000-1182 (Linking)
VI  - 30
IP  - 3
DP  - 2012 Jun
TI  - [Change of calcium channel alpha-2-delta-1 subunit expression levels in 
      trigeminal neuralgia rats].
PG  - 314-6
AB  - OBJECTIVE: To determine the expression levels of calcium channel alpha-2-delta-1 
      (Cavalpha2delta-1) subunit in trigeminal ganglia (TG) and trigeminal spinal 
      subnucleus caudalis C1-C2 spinal cervical dorsal horn(Vc/C2) after infraorbital 
      nerve (ION) ligation injury in relation to the development of neuropathic 
      nociception. METHODS: Twelve male SD rats were divided into two groups randomly, 
      with 6 rats for each. In the ligation group, the ION was ligated by chromic gut 
      loosely. In the sham operation group, the ION was exposed under same procedure 
      but not ligated. The behavioral tests were conducted before 1 d and after 3, 6, 
      9, 12, 15 d with calibrated von Frey filaments. Cavalpha2delta-1 protein levels 
      in TG and Vc/C2 were measured with Western blots 15 days after surgery. RESULTS: 
      Compared with the sham operation group, changes of allodynia to mechanical 
      stimulation on the territory of ligated ION were found from the 9th to 15th day 
      after operation in the ligation group (P<0.05). The expression levels of 
      Cavalpha2delta-1 in TG and Vc/ C2 after ION ligation injury upregulated 
      significantly (P<0.01). CONCLUSION: The expression levels of Cavalpha2delta-1 in 
      TG and Vc/C2 after ION ligation injury were upregulated and it may contribute to 
      the pathogenesis of neuropathic nociception.
FAU - Zhang, Xia
AU  - Zhang X
AD  - Dept. of Anesthesiology, School of Stomatology, China Medical University, 
      Shenyang 110002, China.
FAU - Bai, Xiaofeng
AU  - Bai X
FAU - Zhang, Qian
AU  - Zhang Q
LA  - chi
PT  - Journal Article
PL  - China
TA  - Hua Xi Kou Qiang Yi Xue Za Zhi
JT  - Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal 
      of stomatology
JID - 9422648
RN  - 0 (Cacna2d1 protein, rat)
RN  - 0 (Calcium Channels)
RN  - 0 (Calcium Channels, L-Type)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Calcium
MH  - Calcium Channels
MH  - Calcium Channels, L-Type
MH  - Male
MH  - Rats
MH  - *Rats, Sprague-Dawley
MH  - *Trigeminal Neuralgia
EDAT- 2012/07/10 06:00
MHDA- 2015/06/16 06:00
CRDT- 2012/07/10 06:00
PHST- 2012/07/10 06:00 [entrez]
PHST- 2012/07/10 06:00 [pubmed]
PHST- 2015/06/16 06:00 [medline]
PST - ppublish
SO  - Hua Xi Kou Qiang Yi Xue Za Zhi. 2012 Jun;30(3):314-6.