PMID- 22772150
OWN - NLM
STAT- MEDLINE
DCOM- 20130524
LR  - 20211021
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 23
IP  - 1
DP  - 2013 Jan
TI  - Macrocyclic contrast agents for magnetic resonance imaging of chronic myocardial 
      infarction: intraindividual comparison of gadobutrol and gadoterate meglumine.
PG  - 108-14
LID - 10.1007/s00330-012-2563-6 [doi]
AB  - OBJECTIVES: To compare 0.15 mmol/kg gadobutrol for late gadolinium enhancement 
      (LGE) imaging of chronic myocardial infarction with a relaxivity-adjusted dose of 
      gadoterate meglumine (Gd-DOTA). METHODS: Seventeen patients with suspected 
      chronic myocardial infarction underwent LGE imaging at 1.5 T, acquiring an 
      inversion-recovery-prepared gradient echo sequence 15 min after contrast agent 
      administration. Each patient underwent LGE imaging twice, once after 
      administration of 0.15 mmol/kg gadobutrol (r1 = 5.2 l mmol(-1) s(-1)) and after 
      0.22 mmol/kg Gd-DOTA (r1 = 3.6 l mmol(-1) s(-1)). Two readers independently 
      determined infarct size and contrast-to-noise ratios of infarcted myocardium to 
      remote myocardium (CNR(remote)) and to the left ventricular lumen (CNR(lumen)). 
      RESULTS: LGE was present in 14 patients. Infarct sizes determined after 
      administration of gadobutrol [23.4 ml; 95 % CI (14.4; 32.5)] and Gd-DOTA [22.1 
      ml; 95 % CI (13.0; 31.1)] were not statistically different (P = 0.22). The 
      CNR(remote) of LGE in infarcted myocardium on gadobutrol- and Gd-DOTA-enhanced 
      images was 44.1 [95 % CI (31.0; 57.1)] and 45.2 [95 % CI (32.2; 58.3)], 
      respectively (P = 0.73). CNR(lumen) was significantly higher on 
      gadobutrol-enhanced LGE images [12.7; 95 % CI (2.5; 23.0) versus 6.8; 95 % CI 
      (-3.5; 17.0); P = 0.02]. CONCLUSION: At relaxivity-adjusted doses, gadobutrol and 
      Gd-DOTA yielded similar infarct sizes with superior contrast between infarcted 
      myocardium and left ventricular lumen on gadobutrol-enhanced images.
FAU - Wagner, Moritz
AU  - Wagner M
AD  - Department of Radiology, Charite-Universitatsmedizin Berlin, Charite Campus 
      Mitte, Chariteplatz 1, 10117, Berlin, Germany. moritz.wagner@charite.de
FAU - Schilling, Rene
AU  - Schilling R
FAU - Doeblin, Patrick
AU  - Doeblin P
FAU - Huppertz, Alexander
AU  - Huppertz A
FAU - Luhur, Reny
AU  - Luhur R
FAU - Schwenke, Carsten
AU  - Schwenke C
FAU - Maurer, Martin
AU  - Maurer M
FAU - Hamm, Bernd
AU  - Hamm B
FAU - Taupitz, Matthias
AU  - Taupitz M
FAU - Durmus, Tahir
AU  - Durmus T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20120708
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 1BJ477IO2L (gadobutrol)
RN  - 6HG8UB2MUY (Meglumine)
RN  - K2I13DR72L (Gadolinium DTPA)
RN  - L0ND3981AG (gadoterate meglumine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chronic Disease
MH  - Contrast Media
MH  - Female
MH  - *Gadolinium DTPA
MH  - Humans
MH  - Least-Squares Analysis
MH  - Linear Models
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - *Meglumine
MH  - Middle Aged
MH  - Myocardial Infarction/*diagnosis
MH  - *Organometallic Compounds
MH  - Prospective Studies
MH  - Statistics, Nonparametric
EDAT- 2012/07/10 06:00
MHDA- 2013/05/28 06:00
CRDT- 2012/07/10 06:00
PHST- 2012/03/11 00:00 [received]
PHST- 2012/05/24 00:00 [accepted]
PHST- 2012/05/18 00:00 [revised]
PHST- 2012/07/10 06:00 [entrez]
PHST- 2012/07/10 06:00 [pubmed]
PHST- 2013/05/28 06:00 [medline]
AID - 10.1007/s00330-012-2563-6 [doi]
PST - ppublish
SO  - Eur Radiol. 2013 Jan;23(1):108-14. doi: 10.1007/s00330-012-2563-6. Epub 2012 Jul 
      8.