PMID- 22772363
OWN - NLM
STAT- MEDLINE
DCOM- 20121029
LR  - 20131121
IS  - 1544-0591 (Electronic)
IS  - 0022-0345 (Linking)
VI  - 91
IP  - 9
DP  - 2012 Sep
TI  - Convergent pre-motoneuronal inputs to single trigeminal motoneurons.
PG  - 888-93
LID - 10.1177/0022034512453724 [doi]
AB  - Because pre-motor neurons targeting trigeminal motoneurons are located in various 
      regions, including the supratrigeminal (SupV) and intertrigeminal (IntV) regions, 
      the principal sensory trigeminal nucleus (PrV), and the region dorsal to the PrV 
      (dRt), a single trigeminal motoneuron may receive differential convergent inputs 
      from these regions. We thus examined the properties of synaptic inputs from these 
      regions to masseter motoneurons (MMNs) and digastric motoneurons (DMNs) in 
      brainstem slice preparations obtained from P1-5 neonatal rats, using whole-cell 
      recordings and laser photolysis of caged glutamate. Photostimulation of multiple 
      regions within the SupV, IntV, PrV, and dRt induced post-synaptic currents (PSCs) 
      in 14 of 19 MMNs and 18 of 26 DMNs. Furthermore, the stimulation of the lateral 
      SupV significantly induced burst PSCs in MMNs more often than low-frequency PSCs 
      in MMNs or burst PSCs in DMNs. Similar results were obtained in the presence of 
      the GABA(A) receptor antagonist SR95531 and the glycine receptor antagonist 
      strychnine. These results suggest that both neonatal MMNs and DMNs receive 
      convergent glutamatergic inputs from the SupV, IntV, PrV, and dRt, and that the 
      lateral SupV sends burst inputs predominantly to the MMNs. Such convergent 
      pre-motoneuronal inputs to trigeminal motoneurons may contribute to the proper 
      execution of neonatal oro-motor functions.
FAU - Nonaka, M
AU  - Nonaka M
AD  - Department of Oral Anesthesia, Showa University School of Dentistry, 1-5-8 
      Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
FAU - Nishimura, A
AU  - Nishimura A
FAU - Nakamura, S
AU  - Nakamura S
FAU - Nakayama, K
AU  - Nakayama K
FAU - Mochizuki, A
AU  - Mochizuki A
FAU - Iijima, T
AU  - Iijima T
FAU - Inoue, T
AU  - Inoue T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120705
PL  - United States
TA  - J Dent Res
JT  - Journal of dental research
JID - 0354343
RN  - 0 (Receptors, Glutamate)
RN  - 3KX376GY7L (Glutamic Acid)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Glutamic Acid/physiology
MH  - Masseter Muscle/*innervation
MH  - Motor Neurons/*physiology
MH  - Neck Muscles/*innervation
MH  - Patch-Clamp Techniques
MH  - Photic Stimulation
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Glutamate/drug effects
MH  - Signal Processing, Computer-Assisted
MH  - Synaptic Transmission/*physiology
MH  - Trigeminal Nuclei/*physiology
EDAT- 2012/07/10 06:00
MHDA- 2012/10/30 06:00
CRDT- 2012/07/10 06:00
PHST- 2012/07/10 06:00 [entrez]
PHST- 2012/07/10 06:00 [pubmed]
PHST- 2012/10/30 06:00 [medline]
AID - 0022034512453724 [pii]
AID - 10.1177/0022034512453724 [doi]
PST - ppublish
SO  - J Dent Res. 2012 Sep;91(9):888-93. doi: 10.1177/0022034512453724. Epub 2012 Jul 
      5.