PMID- 22772366 OWN - NLM STAT- MEDLINE DCOM- 20130524 LR - 20211021 IS - 1432-1084 (Electronic) IS - 0938-7994 (Print) IS - 0938-7994 (Linking) VI - 22 IP - 12 DP - 2012 Dec TI - Value of cardiovascular MR in diagnosing left ventricular non-compaction cardiomyopathy and in discriminating between other cardiomyopathies. PG - 2699-709 LID - 10.1007/s00330-012-2554-7 [doi] AB - OBJECTIVES: To analyse the value of cardiovascular magnetic resonance (CMR)-derived myocardial parameters to differentiate left ventricular non-compaction cardiomyopathy (LVNC) from other cardiomyopathies and controls. METHODS: We retrospectively analysed 12 patients with LVNC, 11 with dilated and 10 with hypertrophic cardiomyopathy and compared them to 24 controls. LVNC patients had to fulfil standard echocardiographic criteria as well as additional clinical and imaging criteria. Cine steady-state free precession and late gadolinium enhancement (LGE) imaging was performed. The total LV myocardial mass index (LV-MMI), compacted (LV-MMI(compacted)), non-compacted (LV-MMI(non-compacted)), percentage LV-MM(non-compacted), ventricular volumes and function were calculated. Data were compared using analysis of variance and Dunnett's test. Additionally, semi-quantitative segmental analyses of the occurrence of increased trabeculation were performed. RESULTS: Total LV-MMI(non-compacted) and percentage LV-MM(non-compacted) were discriminators between patients with LVCN, healthy controls and those with other cardiomyopathies with cut-offs of 15 g/m(2) and 25 %, respectively. Furthermore, trabeculation in basal segments and a ratio of non-compacted/compacted myocardium of >/=3:1 were criteria for LVNC. A combination of these criteria provided sensitivities and specificities of up to 100 %. None of the LVNC patients demonstrated LGE. CONCLUSIONS: Absolute CMR quantification of the LV-MMI(non-compacted) or the percentage LV-MM(non-compacted) and increased trabeculation in basal segments allows one to reliably diagnose LVNC and to differentiate it from other cardiomyopathies. KEY POINTS: Cardiac magnetic resonance imaging can reliably diagnose left ventricular non-compaction cardiomyopathy. Differentiation of LVNC from other cardiomyopathies and normal hearts is possible. The best diagnostic performance can be achieved if combined MRI criteria for the diagnosis are used. FAU - Grothoff, Matthias AU - Grothoff M AD - Department of Diagnostic and Interventional Radiology, University of Leipzig - Heart Center, Strumpellstr. 39, 04289, Leipzig, Germany. matthias.grothoff@herzzentrum-leipzig.de FAU - Pachowsky, Milena AU - Pachowsky M FAU - Hoffmann, Janine AU - Hoffmann J FAU - Posch, Maximilian AU - Posch M FAU - Klaassen, Sabine AU - Klaassen S FAU - Lehmkuhl, Lukas AU - Lehmkuhl L FAU - Gutberlet, Matthias AU - Gutberlet M LA - eng PT - Journal Article DEP - 20120710 PL - Germany TA - Eur Radiol JT - European radiology JID - 9114774 RN - 0 (Contrast Media) RN - K2I13DR72L (Gadolinium DTPA) SB - IM MH - Adolescent MH - Adult MH - Aged MH - Analysis of Variance MH - Cardiomyopathies/*diagnosis MH - Case-Control Studies MH - Chi-Square Distribution MH - Child MH - Contrast Media MH - Diagnosis, Differential MH - Echocardiography MH - Female MH - Gadolinium DTPA MH - Humans MH - Image Interpretation, Computer-Assisted MH - Isolated Noncompaction of the Ventricular Myocardium/*diagnosis MH - Magnetic Resonance Imaging/*methods MH - Male MH - Middle Aged MH - Predictive Value of Tests MH - Retrospective Studies MH - Sensitivity and Specificity PMC - PMC3486997 EDAT- 2012/07/10 06:00 MHDA- 2013/05/28 06:00 PMCR- 2012/07/10 CRDT- 2012/07/10 06:00 PHST- 2012/01/27 00:00 [received] PHST- 2012/05/24 00:00 [accepted] PHST- 2012/05/21 00:00 [revised] PHST- 2012/07/10 06:00 [entrez] PHST- 2012/07/10 06:00 [pubmed] PHST- 2013/05/28 06:00 [medline] PHST- 2012/07/10 00:00 [pmc-release] AID - 2554 [pii] AID - 10.1007/s00330-012-2554-7 [doi] PST - ppublish SO - Eur Radiol. 2012 Dec;22(12):2699-709. doi: 10.1007/s00330-012-2554-7. Epub 2012 Jul 10.