PMID- 22772567
OWN - NLM
STAT- MEDLINE
DCOM- 20121102
LR  - 20151119
IS  - 1464-0333 (Electronic)
IS  - 1464-0325 (Linking)
VI  - 14
IP  - 8
DP  - 2012 Aug
TI  - Bioaccumulation and related effects of PCBs and organochlorinated pesticides in 
      freshwater fish Hypostomus commersoni.
PG  - 2154-63
LID - 10.1039/c2em10863a [doi]
AB  - Few studies have investigated the bioaccumulation of persistent organic 
      pollutants (POPs) in Brazilian native freshwater fish. In order to evaluate the 
      bioavailability, potential risk to human exposure and the effects of POPs in the 
      fish Hypostomus commersoni, muscle and liver samples of thirteen specimens were 
      collected in a lake located in the city of Ponta Grossa (Parana State, Southern 
      Brazil). Also, the liver and gills were considered for histopathological studies, 
      and oxidative stress was investigated in the liver. Expressive concentrations of 
      POPs were observed in the liver and muscle, with a total of 427 +/- 78.7 and 69.2 +/- 
      18.1 ng g(-1) dry weights of polychlorinated biphenyls (PCBs), respectively. 
      Negative correlations between the concentration of several POPs and glutathione 
      S-transferase and glucose-6-phosphate dehydrogenase were found. Otherwise, the 
      cholinesterase activity in the muscle and brain presented positive correlations 
      with the concentration of POPs. The hepatic bioaccumulation of some banned 
      pesticides like aldrin, dieldrin and DDT was associated with various 
      histopathological findings in the liver and gills. Necrotic areas, fibrosis, 
      leukocyte infiltration, and the absence of macrophage centers were observed in 
      the liver, indicating both chronic exposure and immunological suppression. 
      Neoplasic changes were observed in the gills, confirming the carcinogenic 
      potential reported for some of the investigated pollutants. The current work was 
      the first to study the bioaccumulation of POPs in H. commersoni, an important 
      species in ecological aspects and as a vehicle to human exposure to PCBs and 
      organochlorine pesticides (OCPs).
FAU - Bussolaro, D
AU  - Bussolaro D
AD  - Departamento de Biologia Celular, Universidade Federal do Parana, Caixa Postal 
      19031, CEP: 81, 531-990, Curitiba, PR, Brazil. danielbussolaro@hotmail.com
FAU - Filipak Neto, F
AU  - Filipak Neto F
FAU - Glinski, A
AU  - Glinski A
FAU - Roche, H
AU  - Roche H
FAU - Guiloski, I C
AU  - Guiloski IC
FAU - Mela, M
AU  - Mela M
FAU - Silva de Assis, H C
AU  - Silva de Assis HC
FAU - Oliveira Ribeiro, C A
AU  - Oliveira Ribeiro CA
LA  - eng
PT  - Journal Article
DEP - 20120709
PL  - England
TA  - J Environ Monit
JT  - Journal of environmental monitoring : JEM
JID - 100968688
RN  - 0 (Biomarkers)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - 0 (Water Pollutants, Chemical)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Brazil
MH  - Environmental Monitoring
MH  - Fishes
MH  - Gills/drug effects/metabolism/pathology
MH  - Hydrocarbons, Chlorinated/metabolism/toxicity
MH  - Liver/drug effects/metabolism/pathology
MH  - Muscles/drug effects/metabolism/pathology
MH  - Pesticides/*metabolism/toxicity
MH  - Polychlorinated Biphenyls/*metabolism/toxicity
MH  - Water Pollutants, Chemical/*metabolism/toxicity
EDAT- 2012/07/10 06:00
MHDA- 2012/11/03 06:00
CRDT- 2012/07/10 06:00
PHST- 2012/07/10 06:00 [entrez]
PHST- 2012/07/10 06:00 [pubmed]
PHST- 2012/11/03 06:00 [medline]
AID - 10.1039/c2em10863a [doi]
PST - ppublish
SO  - J Environ Monit. 2012 Aug;14(8):2154-63. doi: 10.1039/c2em10863a. Epub 2012 Jul 
      9.