PMID- 22773410
OWN - NLM
STAT- MEDLINE
DCOM- 20130228
LR  - 20171116
IS  - 1439-0221 (Electronic)
IS  - 0032-0943 (Linking)
VI  - 78
IP  - 12
DP  - 2012 Aug
TI  - Deoxyschizandrin isolated from the fruits of Schisandra chinensis ameliorates 
      Abeta(1)(-)(4)(2)-induced memory impairment in mice.
PG  - 1332-6
LID - 10.1055/s-0032-1315019 [doi]
AB  - In the present study, we examined the effects of deoxyschisandrin (DS) from 
      Schisandra chinensis on the amyloid-beta(1)(-)(4)(2) (Abeta(1)(-)(4)(2))-induced memory impairment 
      in mice and investigated the possible antioxidative mechanism. Mice were given an 
      intracerebroventricular (i. c. v.) injection with the aggregated Abeta(1)(-)(4)(2) and then 
      treated with DS (4, 12, and 36 mg/kg body weight) or donepezil (DPZ), a positive 
      control drug (0.65 mg/kg), by intragastric infusion for 14 days. Non-cognitive 
      disturbances and cognitive performance were evaluated by the locomotor activity, 
      Y-maze, and water maze tests. Antioxidative enzyme activities including 
      superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) and levels of 
      malondialdehyde (MDA), glutathione (GSH), and oxidized glutathione (GSSG) within 
      the cerebral cortex and hippocampus of mice were measured to investigate the 
      mechanism. Our results showed that DS significantly improved Abeta(1)(-)(4)(2)-induced 
      short-term and spatial memory impairments in the Y-maze and water maze tests. 
      Furthermore, in the cerebral cortex and hippocampus of mice, the reduced 
      activities of SOD and GSH-px, the GSH level, and the GSH/GSSG ratio were 
      increased, and increased levels of MDA and GSSG were reduced following treatment 
      with DS, although the improvement of GSH and the reduction of GSSG levels were 
      not marked. These results suggest that DS is a potential cognitive enhancer in 
      Alzheimer's disease through its antioxidative action.
CI  - Georg Thieme Verlag KG Stuttgart . New York.
FAU - Hu, Di
AU  - Hu D
AD  - Department and Utilization Key Laboratory of Northeast Plant Materials, School of 
      Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 
      China.
FAU - Li, Changxia
AU  - Li C
FAU - Han, Na
AU  - Han N
FAU - Miao, Lijing
AU  - Miao L
FAU - Wang, Dong
AU  - Wang D
FAU - Liu, Zhihui
AU  - Liu Z
FAU - Wang, Hua
AU  - Wang H
FAU - Yin, Jun
AU  - Yin J
LA  - eng
PT  - Journal Article
DEP - 20120706
PL  - Germany
TA  - Planta Med
JT  - Planta medica
JID - 0066751
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Antioxidants)
RN  - 0 (Cyclooctanes)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Lignans)
RN  - 0 (Polycyclic Compounds)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 74XQL5DO3S (schizandrin A)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Alzheimer Disease/drug therapy
MH  - Amyloid beta-Peptides
MH  - Animals
MH  - Antioxidants/*pharmacology
MH  - Cerebral Cortex/metabolism
MH  - Cyclooctanes/isolation & purification/*pharmacology
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Fruit/chemistry
MH  - Glutathione/metabolism
MH  - Glutathione Peroxidase/metabolism
MH  - Hippocampus/metabolism
MH  - Lignans/isolation & purification/*pharmacology
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Maze Learning/drug effects
MH  - Memory Disorders/chemically induced/*drug therapy/metabolism
MH  - Mice
MH  - Polycyclic Compounds/isolation & purification/*pharmacology
MH  - Schisandra/*chemistry
MH  - Superoxide Dismutase/metabolism
EDAT- 2012/07/10 06:00
MHDA- 2013/03/01 06:00
CRDT- 2012/07/10 06:00
PHST- 2012/07/10 06:00 [entrez]
PHST- 2012/07/10 06:00 [pubmed]
PHST- 2013/03/01 06:00 [medline]
AID - 10.1055/s-0032-1315019 [doi]
PST - ppublish
SO  - Planta Med. 2012 Aug;78(12):1332-6. doi: 10.1055/s-0032-1315019. Epub 2012 Jul 6.