PMID- 22774568
OWN - NLM
STAT- MEDLINE
DCOM- 20121009
LR  - 20151119
IS  - 0047-1860 (Print)
IS  - 0047-1860 (Linking)
VI  - 60
IP  - 5
DP  - 2012 May
TI  - [Performance and clinical utility of a high-sensitivity troponin T assay].
PG  - 407-13
AB  - In the present study, we evaluated the performance and clinical utility of a 
      high-sensitivity troponin T (hs-cTnT) assay. The within- and between-assay 
      variations (coefficients of variation: CV) in the low and high concentrations of 
      troponin T in serum samples were 0.84% to 3.34%, respectively. Analysis of 
      interferents showed that only hemoglobin negatively influenced the assay results. 
      Blank assay was < 0.001 ng/mL, and a limit of quantification (10% CV) was found 
      at 0.005 ng/mL. The correlation coefficient (r) between hs-cTnT and the 
      conventional assay was 0.997 (p < 0.000). The high-sensitivity assay system could 
      detect cTnT in 88% of samples in which the conventional assay could not detect 
      any immunoreactivity. The 99th percentile in healthy subjects, determined using 
      559 samples from medical checkups, was 0.011 ng/mL. There was a gender difference 
      (hs-cTnT levels were higher in men than in women), and hs-cTnT levels increased 
      with age. Because hs-cTnT level exceeded 0.011 ng/mL approximately 2 hours after 
      the onset of chest pain in patients with acute myocardial infarction, hs-cTnT can 
      serve as a biomarker for early detection of myocardial infarction. There was a 
      positive correlation (r = 0.491, p < 0.001) between hs-cTnT and NT-proBNP, and 
      hs-cTnT levels increased with the progression of the disease state, as assessed 
      using New York Heart Association (NYHA) classification. These findings indicate 
      that the hs-cTnT assay is sensitive enough to diagnose early-stage acute 
      myocardial infarction and congestive heart failure.
FAU - Okura, Hiroe
AU  - Okura H
AD  - Department of Clinical Laboratory, Kansai Medical University Hirakata Hospital, 
      Hirakata 573-1191, Japan.
FAU - Suzuki, Reiko
AU  - Suzuki R
FAU - Sugibayashi, Sachiyo
AU  - Sugibayashi S
FAU - Yoshika, Masamichi
AU  - Yoshika M
FAU - Takahashi, Hakuo
AU  - Takahashi H
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Rinsho Byori
JT  - Rinsho byori. The Japanese journal of clinical pathology
JID - 2984781R
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (Troponin T)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Female
MH  - Humans
MH  - Immunoassay/*methods
MH  - Luminescent Measurements/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*blood/*diagnosis
MH  - Natriuretic Peptide, Brain/blood
MH  - Peptide Fragments/blood
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Troponin T/*blood
MH  - Young Adult
EDAT- 2012/07/11 06:00
MHDA- 2012/10/10 06:00
CRDT- 2012/07/11 06:00
PHST- 2012/07/11 06:00 [entrez]
PHST- 2012/07/11 06:00 [pubmed]
PHST- 2012/10/10 06:00 [medline]
PST - ppublish
SO  - Rinsho Byori. 2012 May;60(5):407-13.