PMID- 22774780
OWN - NLM
STAT- MEDLINE
DCOM- 20130102
LR  - 20211021
IS  - 1469-7580 (Electronic)
IS  - 0021-8782 (Print)
IS  - 0021-8782 (Linking)
VI  - 221
IP  - 4
DP  - 2012 Oct
TI  - A putative functional vomeronasal system in anuran tadpoles.
PG  - 364-72
LID - 10.1111/j.1469-7580.2012.01543.x [doi]
AB  - We investigated the occurrence and anatomy of the vomeronasal system (VNS) in 
      tadpoles of 13 different anuran species. All of the species possessed a 
      morphologically fully developed VNS with a highly conserved anatomical 
      organisation. We found that a bean-shaped vomeronasal organ (VNO) developed early 
      in the tadpoles, during the final embryonic stages, and was located in the 
      anteromedial nasal region. Histology revealed the presence of bipolar 
      chemosensory neurones in the VNO that were immunoreactive for the Galphao protein. 
      Tract-tracing experiments demonstrated that chemosensory neurones from the VNO 
      reach specific areas in the brain, where a discernible accessory olfactory bulb 
      (AOB) could be observed. The AOB was located in the ventrolateral side of the 
      anterior telencephalon, somewhat caudal to the main olfactory bulb. 
      Synaptophysin-like immunodetection revealed that synaptic contacts between VNO 
      and AOB are established during early larval stages. Moreover, using lectin 
      staining, we identified glomerular structures in the AOB in most of the species 
      that we examined. According to our findings, a significant maturation in the VNS 
      is achieved in anuran larvae. Recent published evidence strongly suggests that 
      the VNS appeared early in vertebrate evolution and was already present in the 
      aquatic last common ancestor of lungfish and tetrapods. In this context, tadpoles 
      may be a good model in which to investigate the anatomical, biochemical and 
      functional aspects of the VNS in an aquatic environment.
CI  - (c) 2012 The Authors Journal of Anatomy (c) 2012 Anatomical Society.
FAU - Jungblut, Lucas David
AU  - Jungblut LD
AD  - Laboratorio de Biologia del Desarrollo, Departamento de Biodiversidad y Biologia 
      Experimental, Facultad de Ciencias Exactas y Naturales, Instituto de Fisiologia 
      Biologia Molecular y Neurociencias (IFIBYNE-CONICET), Universidad de Buenos 
      Aires, Buenos Aires, Argentina.
FAU - Pozzi, Andrea Gabriela
AU  - Pozzi AG
FAU - Paz, Dante Agustin
AU  - Paz DA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120708
PL  - England
TA  - J Anat
JT  - Journal of anatomy
JID - 0137162
SB  - IM
MH  - Animals
MH  - Anura/*anatomy & histology/growth & development
MH  - Immunohistochemistry
MH  - Larva/anatomy & histology
MH  - Olfactory Bulb/anatomy & histology
MH  - Species Specificity
MH  - Vomeronasal Organ/*anatomy & histology/growth & development
PMC - PMC3458256
EDAT- 2012/07/11 06:00
MHDA- 2013/01/03 06:00
PMCR- 2014/10/01
CRDT- 2012/07/11 06:00
PHST- 2012/06/20 00:00 [accepted]
PHST- 2012/07/11 06:00 [entrez]
PHST- 2012/07/11 06:00 [pubmed]
PHST- 2013/01/03 06:00 [medline]
PHST- 2014/10/01 00:00 [pmc-release]
AID - 10.1111/j.1469-7580.2012.01543.x [doi]
PST - ppublish
SO  - J Anat. 2012 Oct;221(4):364-72. doi: 10.1111/j.1469-7580.2012.01543.x. Epub 2012 
      Jul 8.