PMID- 22776095 OWN - NLM STAT- MEDLINE DCOM- 20150622 LR - 20211021 IS - 1478-6362 (Electronic) IS - 1478-6354 (Print) IS - 1478-6354 (Linking) VI - 14 IP - 4 DP - 2012 Jul 9 TI - Changes in pain and insulin-like growth factor 1 in fibromyalgia during exercise: the involvement of cerebrospinal inflammatory factors and neuropeptides. PG - R162 LID - 10.1186/ar3902 [doi] AB - INTRODUCTION: Fibromyalgia (FM) is characterized by chronic pain. Impaired growth hormone responses and reduced serum insulin-like growth factor 1 (IGF-1) are common in FM. The aim was to examine changes in serum IGF-1, cerebrospinal fluid (CSF), neuropeptides, and cytokines during aerobic exercise in FM patients. METHODS: In total, 49 patients (median age, 52 years) with FM were included in the study. They were randomized to either the moderate- to high-intensity Nordic Walking (NW) program (n = 26) or the supervised low-intensity walking (LIW) program (n = 23). Patients participated in blood tests before and after 15 weeks of aerobic exercise. Changes in serum levels of free IGF-1, pain rating on a 0- to 100-mm scale, pain threshold, and 6-minute walk test (6MWT) were examined. CSF, neuropeptides, matrix metalloproteinase 3 (MMP-3), and inflammatory cytokines were determined. Nonparametric tests were used for group comparisons and correlation analyses. RESULTS: Serum free IGF-1 levels did not change during 15 weeks of exercise between the two groups, although the 6MWT significantly improved in the NW group (p = 0.033) when compared with LIW. Pain did not significantly change in any of the groups, but tended to decrease (p = 0.052) over time in the total group. A tendency toward a correlation was noted between baseline IGF-1 and a decrease of pain in response to exercise (r = 0.278; p = 0.059). When adjusted for age, this tendency disappeared. The change in serum free IGF-1 correlated positively with an alteration in CSF substance P (SP) levels (rs = 0.495; p = 0.072), neuropeptide Y (NPY) (rs = 0.802; p = 0.001), and pain threshold (rs = 0.276; p = 0.058). Differing CSF SP levels correlated positively to a change in pain threshold (rs = 0.600; p = 0.023), whereas the shift in CSF MMP-3 inversely correlated with an altered pain threshold (rs = -0.569; p = 0.034). CONCLUSIONS: The baseline level of serum free IGF-1 did not change during high or low intensity of aerobic exercise. Changes in IGF-1 correlated positively with a variation in CSF SP, NPY, and pain threshold. These data indicate a beneficial role of IGF-1 during exercise in FM. FAU - Bjersing, Jan L AU - Bjersing JL FAU - Dehlin, Mats AU - Dehlin M FAU - Erlandsson, Malin AU - Erlandsson M FAU - Bokarewa, Maria I AU - Bokarewa MI FAU - Mannerkorpi, Kaisa AU - Mannerkorpi K LA - eng SI - ClinicalTrials.gov/NCT00643006 PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20120709 PL - England TA - Arthritis Res Ther JT - Arthritis research & therapy JID - 101154438 RN - 0 (Biomarkers) RN - 0 (Inflammation Mediators) RN - 0 (Neuropeptides) RN - 67763-96-6 (Insulin-Like Growth Factor I) SB - IM MH - Biomarkers/blood/cerebrospinal fluid MH - Exercise/*physiology MH - Female MH - Fibromyalgia/blood/*cerebrospinal fluid/diagnosis MH - Humans MH - Inflammation Mediators/blood/*cerebrospinal fluid MH - Insulin-Like Growth Factor I/*cerebrospinal fluid MH - Middle Aged MH - Neuropeptides/blood/*cerebrospinal fluid MH - Pain/blood/*cerebrospinal fluid/diagnosis PMC - PMC3580554 EDAT- 2012/07/11 06:00 MHDA- 2015/06/24 06:00 PMCR- 2012/07/09 CRDT- 2012/07/11 06:00 PHST- 2012/02/09 00:00 [received] PHST- 2012/07/09 00:00 [accepted] PHST- 2012/07/11 06:00 [entrez] PHST- 2012/07/11 06:00 [pubmed] PHST- 2015/06/24 06:00 [medline] PHST- 2012/07/09 00:00 [pmc-release] AID - ar3902 [pii] AID - 10.1186/ar3902 [doi] PST - epublish SO - Arthritis Res Ther. 2012 Jul 9;14(4):R162. doi: 10.1186/ar3902.