PMID- 22776327
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20120914
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 118
DP  - 2012 Oct
TI  - Personal exposure to specific volatile organic compounds and acute changes in 
      lung function and heart rate variability among urban cyclists.
PG  - 118-23
LID - S0013-9351(12)00188-0 [pii]
LID - 10.1016/j.envres.2012.06.005 [doi]
AB  - BACKGROUND: Few studies have examined the acute cardiorespiratory effects of 
      specific volatile organic compound (VOC) exposures from traffic pollution. 
      METHODS: A cross-over study was conducted among 42 healthy adults during summer 
      2010 in Ottawa, Canada. Participants cycled for 1-h along high and low-traffic 
      routes and VOC exposures were determined along each route. Lung function, exhaled 
      nitric oxide, and heart rate variability were monitored before cycling and 1-4h 
      after the start of cycling. Bayesian hierarchical models were used to examine the 
      relationship between 26 VOCs and acute changes in clinical outcomes adjusted for 
      potential confounding factors. RESULTS: Each inter-quartile range (IQR) increase 
      in propane/butane exposure was associated with a 2.0 millisecond (ms) (95% CI: 
      0.65, 3.2) increase in SDNN (standard deviation of normal-to-normal intervals), a 
      24 ms(2) (95% CI: 6.6, 41) increase in HF (high frequency power), and a 65 ms(2) 
      (95% CI: 11, 118) increase in LF (low frequency power) in the hours following 
      cycling. IQR increases in ethane and isoprene were associated with a 5.8 ms (95% 
      CI: -9.8, -1.7): decrease in SDNN and a 24 ms(2) (95% CI: -44, -7.9) decrease in 
      HF, respectively. IQR increases in benzene exposure were associated with a 1.7 
      ppb (95% CI: 1.1, 2.3) increase in exhaled nitric oxide and each IQR increase in 
      3-methylhexane exposure was associated with a 102 mL (95% CI: -157, -47) decrease 
      in forced expiratory volume in 1-s. CONCLUSIONS: Exposure to traffic-related VOCs 
      may contribute to acute changes in lung function, inflammation, or heart rate 
      variability.
CI  - Crown Copyright (c) 2012. Published by Elsevier Inc. All rights reserved.
FAU - Weichenthal, Scott
AU  - Weichenthal S
AD  - Health Canada, Air Health Sciences Division, Ottawa, ON, Canada. 
      scott.weichenthal@hc-sc.gc.ca
FAU - Kulka, Ryan
AU  - Kulka R
FAU - Belisle, Patrick
AU  - Belisle P
FAU - Joseph, Lawrence
AU  - Joseph L
FAU - Dubeau, Aimee
AU  - Dubeau A
FAU - Martin, Christina
AU  - Martin C
FAU - Wang, Daniel
AU  - Wang D
FAU - Dales, Robert
AU  - Dales R
LA  - eng
PT  - Journal Article
DEP - 20120708
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Air Pollutants)
RN  - 0 (Volatile Organic Compounds)
SB  - IM
MH  - Air Pollutants/*toxicity
MH  - Bayes Theorem
MH  - *Bicycling
MH  - *Environmental Exposure
MH  - Heart Rate/*drug effects
MH  - Humans
MH  - Lung/*drug effects/physiology
MH  - *Urban Population
MH  - Volatile Organic Compounds/*toxicity
EDAT- 2012/07/11 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/07/11 06:00
PHST- 2012/02/02 00:00 [received]
PHST- 2012/05/23 00:00 [revised]
PHST- 2012/06/14 00:00 [accepted]
PHST- 2012/07/11 06:00 [entrez]
PHST- 2012/07/11 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - S0013-9351(12)00188-0 [pii]
AID - 10.1016/j.envres.2012.06.005 [doi]
PST - ppublish
SO  - Environ Res. 2012 Oct;118:118-23. doi: 10.1016/j.envres.2012.06.005. Epub 2012 
      Jul 8.