PMID- 22776852
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20221207
IS  - 1663-2826 (Electronic)
IS  - 1663-2818 (Linking)
VI  - 77
IP  - 6
DP  - 2012
TI  - Low serum adiponectin levels in Korean children with a family history of type 2 
      diabetes mellitus.
PG  - 382-7
AB  - BACKGROUND/AIMS: The current worldwide increases of type 2 diabetes mellitus 
      (T2DM) in children coincide with increases in the prevalence of obesity. We 
      investigated the insulin resistance and adiponectin levels of children and 
      adolescents with a family history of T2DM (FHD). METHODS: Our sample included 131 
      children and adolescents aged 8-15 years. Fasting plasma glucose, lipids, fasting 
      insulin, adiponectin levels and HOMA-IR were analyzed according to FHD and 
      obesity. Oral glucose tolerance tests were performed in all subjects except 
      non-obese subjects without FHD. RESULTS: Adiponectin levels of subjects with FHD 
      were significantly lower than those of subjects without FHD in both the obese and 
      nonobese groups. HOMA-IR was significantly higher in obese subjects with FHD than 
      in those without FHD. Adiponectin levels were found to be independently 
      associated with FHD and Matsuda index. The frequency of impaired glucose 
      tolerance in obese subjects with FHD was more than four times higher compared to 
      obese subjects without FHD. CONCLUSION: Our results suggest that FHD could be a 
      risk factor of T2DM in obese Korean children, especially with low serum levels of 
      adiponectin.
FAU - Oh, Yeon Joung
AU  - Oh YJ
AD  - Department of Pediatrics, Sahm Yook Medical Center, Seoul, Korea.
FAU - Nam, Hyo-Kyoung
AU  - Nam HK
FAU - Rhie, Young Jun
AU  - Rhie YJ
FAU - Park, Sang Hee
AU  - Park SH
FAU - Lee, Kee-Hyoung
AU  - Lee KH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Horm Res Paediatr
JT  - Hormone research in paediatrics
JID - 101525157
RN  - 0 (ADIPOQ protein, human)
RN  - 0 (Adiponectin)
SB  - IM
MH  - Adiponectin/*blood
MH  - Adolescent
MH  - Asian People/statistics & numerical data
MH  - Body Mass Index
MH  - Child
MH  - *Diabetes Mellitus, Type 2/blood/epidemiology/ethnology
MH  - *Family Health
MH  - Female
MH  - Glucose Intolerance/blood/epidemiology/ethnology
MH  - Humans
MH  - Insulin Resistance/physiology
MH  - Male
MH  - Obesity/blood/epidemiology/ethnology
MH  - Republic of Korea/epidemiology
EDAT- 2012/07/11 06:00
MHDA- 2013/01/11 06:00
CRDT- 2012/07/11 06:00
PHST- 2011/12/14 00:00 [received]
PHST- 2012/04/26 00:00 [accepted]
PHST- 2012/07/11 06:00 [entrez]
PHST- 2012/07/11 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
AID - 000339154 [pii]
AID - 10.1159/000339154 [doi]
PST - ppublish
SO  - Horm Res Paediatr. 2012;77(6):382-7. doi: 10.1159/000339154.