PMID- 22777717
OWN - NLM
STAT- MEDLINE
DCOM- 20140528
LR  - 20211203
IS  - 1940-2465 (Electronic)
IS  - 1066-8969 (Linking)
VI  - 21
IP  - 2
DP  - 2013 Apr
TI  - Clinicopathological significance of NUT rearrangements in poorly differentiated 
      malignant tumors of the upper respiratory tract.
PG  - 102-10
LID - 10.1177/1066896912451651 [doi]
AB  - Nuclear protein in testis (NUT) midline carcinoma (NMC) is a highly malignant 
      carcinoma originating from the midline of the body. This study investigated the 
      clinicopathological significance of NUT rearrangements in poorly differentiated 
      malignant tumors (PDMTs) of the upper-respiratory tract (URT) in China. The 
      clinical and pathological features of 155 PDMTs of the URT were reviewed. 
      Epstein-Barr virus (EBV)-encoded RNA and NUT were investigated by in situ 
      hybridization and immunohistochemistry (IHC), respectively. NUT-positive cases 
      were examined by fluorescence in situ hybridization (FISH) and 
      immunohistochemical staining with a set of cytokeratins (CKs) and neuroendocrine 
      markers. One case was observed by transmission electron microscopy. Four cases of 
      poorly differentiated squamous cell carcinomas and sinonasal undifferentiated 
      carcinomas were diffuse positive for NUT by IHC and also stained for antibodies 
      to CKs and P63 but were negative for neuroendocrine markers. Only 2 of these 4 
      cases showed rearrangements of the NUT and BRD4 genes by FISH; both these 
      patients died within 12 months. The remaining 2 patients showed no NUT 
      rearrangement by FISH and did not have an aggressive clinical course. NMC is a 
      rare, poorly differentiated carcinoma, which occurs most often in midline organs, 
      and in this first series from China, affected the sinonasal tract of older adults 
      and was not associated with EBV infection. Determination of NUT protein 
      expression and gene rearrangement can allow the differentiation of NMC from other 
      URT PDMTs. The authors suggest that molecular determination of NUT gene 
      rearrangements should therefore represent the gold standard for NMC diagnosis.
FAU - Fang, Wei
AU  - Fang W
AD  - Department of Pathology, Beijing Tongren Hospital, Capital Medical University, 
      Beijing, China.
FAU - French, Christopher A
AU  - French CA
FAU - Cameron, Michael J
AU  - Cameron MJ
FAU - Han, Yiding
AU  - Han Y
FAU - Liu, Honggang
AU  - Liu H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120709
PL  - United States
TA  - Int J Surg Pathol
JT  - International journal of surgical pathology
JID - 9314927
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (NUTM1 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Oncogene Proteins)
RN  - Sinonasal undifferentiated carcinoma
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/*genetics
MH  - Carcinoma/*genetics/*pathology
MH  - Carcinoma, Squamous Cell/genetics/pathology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Gene Rearrangement
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Male
MH  - Maxillary Sinus Neoplasms/*genetics/*pathology
MH  - Microscopy, Electron, Transmission
MH  - Middle Aged
MH  - Neoplasm Proteins
MH  - Nuclear Proteins/*genetics
MH  - Oncogene Proteins/*genetics
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2012/07/11 06:00
MHDA- 2014/05/29 06:00
CRDT- 2012/07/11 06:00
PHST- 2012/07/11 06:00 [entrez]
PHST- 2012/07/11 06:00 [pubmed]
PHST- 2014/05/29 06:00 [medline]
AID - 1066896912451651 [pii]
AID - 10.1177/1066896912451651 [doi]
PST - ppublish
SO  - Int J Surg Pathol. 2013 Apr;21(2):102-10. doi: 10.1177/1066896912451651. Epub 
      2012 Jul 9.