PMID- 22778022
OWN - NLM
STAT- MEDLINE
DCOM- 20130104
LR  - 20221207
IS  - 1099-1077 (Electronic)
IS  - 0885-6222 (Linking)
VI  - 27
IP  - 4
DP  - 2012 Jul
TI  - No association between the type 2 diabetes mellitus susceptibility gene, SLC30A8 
      and schizophrenia in a Chinese population.
PG  - 392-6
LID - 10.1002/hup.2239 [doi]
AB  - BACKGROUND: The co-occurrence of schizophrenia and type 2 diabetes mellitus 
      (T2DM) has been well documented. Recent genome-wide association studies and 
      meta-analyses have shown robust associations of the solute carrier family 30 
      member 8 (SLC30A8) gene variants with T2DM in various populations. We examined 
      the involvement of the SLC30A8 in the susceptibility to schizophrenia in a Han 
      Chinese population. METHODS: The SLC30A8 rs13266634 gene polymorphism was 
      genotyped in 837 chronic schizophrenic and 1109 unrelated healthy controls by 
      using a case control design. We also assessed clinical symptoms. RESULTS: There 
      were no significant differences in the rs13266634 genotype (chi(2)  = 1.95, df = 2, 
      p = 0.38) and allele (chi(2)  = 0.47, df = 1, p = 0.50) distributions between the 
      patient and control groups. There was no association between rs13266634 and 
      clinical symptoms. CONCLUSION: The SLC30A8 gene variation does not appear to 
      contribute a genetic basis for the co-occurrence of schizophrenia and T2DM.
CI  - Copyright (c) 2012 John Wiley & Sons, Ltd.
FAU - Zhang, Xuan
AU  - Zhang X
AD  - Research Center for Diabetic Complication and Department of Nephrology, the 
      Second Hospital, Jilin University, Changchun, China. zhangxuan2010@yahoo.com.cn
FAU - Guan, Song-Lei
AU  - Guan SL
FAU - Wang, Zhen-Qi
AU  - Wang ZQ
FAU - You, Yang
AU  - You Y
FAU - Sun, Shi-Long
AU  - Sun SL
FAU - Hui, Li
AU  - Hui L
FAU - Miao, Li-Ning
AU  - Miao LN
FAU - Yu, Yaqin
AU  - Yu Y
FAU - Kosten, Thomas R
AU  - Kosten TR
FAU - Zhang, Xiang Yang
AU  - Zhang XY
LA  - eng
GR  - K05-DA0454/DA/NIDA NIH HHS/United States
GR  - P50-DA18827/DA/NIDA NIH HHS/United States
GR  - U01-MH79639/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20120709
PL  - England
TA  - Hum Psychopharmacol
JT  - Human psychopharmacology
JID - 8702539
RN  - 0 (Cation Transport Proteins)
RN  - 0 (SLC30A8 protein, human)
RN  - 0 (Zinc Transporter 8)
SB  - IM
MH  - Adult
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - Cation Transport Proteins/*genetics
MH  - China
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Genetic Variation
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Schizophrenia/*genetics
MH  - Young Adult
MH  - Zinc Transporter 8
EDAT- 2012/07/11 06:00
MHDA- 2013/01/05 06:00
CRDT- 2012/07/11 06:00
PHST- 2012/01/20 00:00 [received]
PHST- 2012/05/23 00:00 [accepted]
PHST- 2012/07/11 06:00 [entrez]
PHST- 2012/07/11 06:00 [pubmed]
PHST- 2013/01/05 06:00 [medline]
AID - 10.1002/hup.2239 [doi]
PST - ppublish
SO  - Hum Psychopharmacol. 2012 Jul;27(4):392-6. doi: 10.1002/hup.2239. Epub 2012 Jul 
      9.