PMID- 22778410
OWN - NLM
STAT- MEDLINE
DCOM- 20121012
LR  - 20220408
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 109
IP  - 30
DP  - 2012 Jul 24
TI  - Adiponectin is critical in determining susceptibility to depressive behaviors and 
      has antidepressant-like activity.
PG  - 12248-53
LID - 10.1073/pnas.1202835109 [doi]
AB  - Depression is a debilitating mental illness and is often comorbid with metabolic 
      disorders such as type 2 diabetes. Adiponectin is an adipocyte-derived hormone 
      with antidiabetic and insulin-sensitizing properties. Here we show that 
      adiponectin levels in plasma are reduced in a chronic social-defeat stress model 
      of depression, which correlates with decreased social interaction time. A 
      reduction in adiponectin levels caused by haploinsufficiency results in increased 
      susceptibility to social aversion, "anhedonia," and learned helplessness and 
      causes impaired glucocorticoid-mediated negative feedback on the 
      hypothalamic-pituitary-adrenal (HPA) axis. Intracerebroventricular (i.c.v.) 
      injection of an adiponectin neutralizing antibody precipitates stress-induced 
      depressive-like behavior. Conversely, i.c.v. administration of exogenous 
      adiponectin produces antidepressant-like behavioral effects in normal-weight mice 
      and in diet-induced obese diabetic mice. Taken together, these results suggest a 
      critical role of adiponectin in depressive-like behaviors and point to a 
      potential innovative therapeutic approach for depressive disorders.
FAU - Liu, Jing
AU  - Liu J
AD  - Department of Pharmacology, University of Texas Health Science Center at San 
      Antonio, San Antonio, TX 78229, USA.
FAU - Guo, Ming
AU  - Guo M
FAU - Zhang, Di
AU  - Zhang D
FAU - Cheng, Shao-Ying
AU  - Cheng SY
FAU - Liu, Meilian
AU  - Liu M
FAU - Ding, Jun
AU  - Ding J
FAU - Scherer, Philipp E
AU  - Scherer PE
FAU - Liu, Feng
AU  - Liu F
FAU - Lu, Xin-Yun
AU  - Lu XY
LA  - eng
GR  - MH076929/MH/NIMH NIH HHS/United States
GR  - R01 MH076929/MH/NIMH NIH HHS/United States
GR  - MH096251/MH/NIMH NIH HHS/United States
GR  - R01 DK076902/DK/NIDDK NIH HHS/United States
GR  - DK55758/DK/NIDDK NIH HHS/United States
GR  - R21 MH096251/MH/NIMH NIH HHS/United States
GR  - DK76902/DK/NIDDK NIH HHS/United States
GR  - R01 DK055758/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120709
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Adiponectin)
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Blood Glucose)
RN  - 0 (Glucocorticoids)
RN  - 0 (Insulin)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Absorptiometry, Photon
MH  - Adiponectin/*blood/*genetics/immunology/metabolism
MH  - Anhedonia/*physiology
MH  - Animals
MH  - Antibodies, Monoclonal/administration & dosage/pharmacology
MH  - Blood Glucose
MH  - Corticosterone/blood
MH  - Depression/*blood/drug therapy/*genetics
MH  - Dexamethasone/administration & dosage
MH  - Genetic Predisposition to Disease/*genetics
MH  - Glucocorticoids/metabolism
MH  - Haploinsufficiency
MH  - In Situ Hybridization
MH  - Infusions, Intraventricular
MH  - Insulin/blood
MH  - Linear Models
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Psychomotor Performance/physiology
MH  - Real-Time Polymerase Chain Reaction
PMC - PMC3409774
COIS- The authors declare no conflict of interest.
EDAT- 2012/07/11 06:00
MHDA- 2012/10/13 06:00
PMCR- 2013/01/24
CRDT- 2012/07/11 06:00
PHST- 2012/07/11 06:00 [entrez]
PHST- 2012/07/11 06:00 [pubmed]
PHST- 2012/10/13 06:00 [medline]
PHST- 2013/01/24 00:00 [pmc-release]
AID - 1202835109 [pii]
AID - 201202835 [pii]
AID - 10.1073/pnas.1202835109 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12248-53. doi: 
      10.1073/pnas.1202835109. Epub 2012 Jul 9.