PMID- 22778523
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 0976-5131 (Electronic)
IS  - 0971-6580 (Print)
IS  - 0971-6580 (Linking)
VI  - 19
IP  - 2
DP  - 2012 May
TI  - Postnatal Exposure to Sodium Arsenite (NaAsO(2)) Induces Long Lasting Effects in 
      Rat Testes.
PG  - 215-22
LID - 10.4103/0971-6580.97225 [doi]
AB  - OBJECTIVE: The present study was undertaken to investigate the effects of early 
      postnatal exposure to sodium arsenite (NaAsO(2)) on rat testis. MATERIALS AND 
      METHODS: Wistar rat pups were administered aqueous solution of NaAsO(2,) 1.5 
      mg/kg body weight (bw) (experimental) and distilled water (control), 
      respectively, by intraperitoneal route (i.p.) from postnatal day (PND) 1 to 14. 
      Testes were collected after 1, 7 and 36 days (at PND 15, 21 and 50) after the 
      treatment period (PND1-14) from the animals and immersion fixed in Bouin's fluid 
      followed by paraffin embedding. Seven micrometer thick serial sections were cut 
      and stained with hematoxylin and eosin for light microscopic observations. At PND 
      50, morphological features of sperms and their counting was carried out besides 
      processing the perfusion-fixed testes for electron microscopy (EM). RESULTS AND 
      CONCLUSIONS: The observations revealed an altered morphology of the seminiferous 
      tubules (ST) along with degeneration and dissociation of spermatogenic cells in 
      the experimental animals at PND 15, 21 and 50. Also, increased number of sperms 
      with abnormal morphology and decreased sperm count was noted in the experimental 
      animals. These features together with electron microscopic observations of 
      abnormal mitochondria and apoptotic nuclei of spermatogonia and spermatocytes 
      could be indicative of long-lasting adverse effects on the rat testis induced by 
      exposure to As during early postnatal period.
FAU - Kaushal, Parul
AU  - Kaushal P
AD  - Department of Anatomy, All India Institute of Medical Sciences, Ansari Nagar, New 
      Delhi- 110029, India.
FAU - Dhar, Pushpa
AU  - Dhar P
FAU - Shivaprasad, Somesh Meludurga
AU  - Shivaprasad SM
FAU - Mehra, Raj D
AU  - Mehra RD
LA  - eng
PT  - Journal Article
PL  - India
TA  - Toxicol Int
JT  - Toxicology international
JID - 101191279
PMC - PMC3388769
OTO - NOTNLM
OT  - Arsenic
OT  - postnatal period
OT  - seminiferous tubules
OT  - sodium arsenite
OT  - spermatozoa
OT  - testis
COIS- Conflict of Interest: None declared.
EDAT- 2012/07/11 06:00
MHDA- 2012/07/11 06:01
PMCR- 2012/05/01
CRDT- 2012/07/11 06:00
PHST- 2012/07/11 06:00 [entrez]
PHST- 2012/07/11 06:00 [pubmed]
PHST- 2012/07/11 06:01 [medline]
PHST- 2012/05/01 00:00 [pmc-release]
AID - TI-19-215 [pii]
AID - 10.4103/0971-6580.97225 [doi]
PST - ppublish
SO  - Toxicol Int. 2012 May;19(2):215-22. doi: 10.4103/0971-6580.97225.