PMID- 22778765
OWN - NLM
STAT- MEDLINE
DCOM- 20121019
LR  - 20230926
IS  - 1740-2530 (Electronic)
IS  - 1740-2522 (Print)
IS  - 1740-2522 (Linking)
VI  - 2012
DP  - 2012
TI  - Distinct characteristics in Japanese dermatitis herpetiformis: a review of all 91 
      Japanese patients over the last 35 years.
PG  - 562168
LID - 10.1155/2012/562168 [doi]
LID - 562168
AB  - We reviewed all 91 Japanese dermatitis herpetiformis (DH) patients reported over 
      the last 35 years. The male-to-female ratio was 2 : 1. The mean age at onset was 
      43.8, and 13 years earlier for female patients. More than half of these Japanese 
      DH patients showed granular IgA deposition in the papillary dermis, and another 
      one-third showed fibrillar IgA deposition. The male patients with granular IgA 
      deposition were 10 years older than those with fibrillar deposition. Whereas 
      patients with granular IgA deposition showed typical distribution of the skin 
      lesions, the predilection sites of DH tended to be spared in patients with 
      fibrillar IgA deposition. Only 3 patients had definite gluten-sensitive 
      enteropathy. There was a statistical difference in the frequency of human 
      leukocyte antigen (HLA)-DR9 between the granular group and controls among 
      Japanese. No patients had HLA-DQ2 or -DQ8, which is frequently found in Caucasian 
      DH patients. The absence of HLA-DQ2/DQ8, the inability to identify celiac disease 
      in most cases, the predominance of fibrillar IgA, and the unusual distribution of 
      clinical lesions in Japanese patients suggest that Japanese DH may be a subset of 
      DH patients and have a pathogenesis which is different from that currently 
      proposed in Caucasian DH patients.
FAU - Ohata, Chika
AU  - Ohata C
AD  - Department of Dermatology, Kurume University School of Medicine, 67 Asahimachi, 
      Kurume, Fukuoka 830-0011, Japan.
FAU - Ishii, Norito
AU  - Ishii N
FAU - Hamada, Takahiro
AU  - Hamada T
FAU - Shimomura, Yutaka
AU  - Shimomura Y
FAU - Niizeki, Hironori
AU  - Niizeki H
FAU - Dainichi, Teruki
AU  - Dainichi T
FAU - Furumura, Minao
AU  - Furumura M
FAU - Tsuruta, Daisuke
AU  - Tsuruta D
FAU - Hashimoto, Takashi
AU  - Hashimoto T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120612
PL  - Egypt
TA  - Clin Dev Immunol
JT  - Clinical & developmental immunology
JID - 101183692
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (Immunoglobulin A)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Asian People
MH  - Child
MH  - Child, Preschool
MH  - Dermatitis Herpetiformis/genetics/*immunology/*pathology
MH  - Female
MH  - HLA-DQ Antigens/genetics/immunology
MH  - Humans
MH  - Immunoglobulin A/immunology/metabolism
MH  - Infant
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Young Adult
PMC - PMC3385876
EDAT- 2012/07/11 06:00
MHDA- 2012/10/20 06:00
PMCR- 2012/06/12
CRDT- 2012/07/11 06:00
PHST- 2012/01/05 00:00 [received]
PHST- 2012/03/22 00:00 [revised]
PHST- 2012/03/29 00:00 [accepted]
PHST- 2012/07/11 06:00 [entrez]
PHST- 2012/07/11 06:00 [pubmed]
PHST- 2012/10/20 06:00 [medline]
PHST- 2012/06/12 00:00 [pmc-release]
AID - 10.1155/2012/562168 [doi]
PST - ppublish
SO  - Clin Dev Immunol. 2012;2012:562168. doi: 10.1155/2012/562168. Epub 2012 Jun 12.