PMID- 22779953
OWN - NLM
STAT- MEDLINE
DCOM- 20121217
LR  - 20161125
IS  - 1364-6893 (Electronic)
IS  - 0144-3615 (Linking)
VI  - 32
IP  - 6
DP  - 2012 Aug
TI  - The role of homocysteine, asymmetric dimethylarginine and nitric oxide in 
      pre-eclampsia.
PG  - 525-8
LID - 10.3109/01443615.2012.693985 [doi]
AB  - Nitric oxide (NO) contributes to vasodilatation that is observed during normal 
      pregnancy. Hyperhomocysteinaemia (HHcy) is a vascular risk factor associated with 
      placental microvascular diseases and pre-eclampsia. Asymmetric dimethylarginine 
      (ADMA), an endogenous inhibitor of endothelial nitric oxide synthase (NOS) has 
      been linked to endothelial dysfunction. Maternal ADMA has been reported to be 
      higher in women with pre-eclampsia and HHcy leads to accumulation of ADMA. The 
      aim of this presented study is to evaluate the alterations of plasma 
      homocysteine, ADMA and NO levels in mild pre-eclampsia. A total of 40 
      pre-eclamptic women and 40 healthy controls were included into the study. Mean 
      systolic and diastolic blood pressure, mean serum homocysteine and ADMA levels 
      were significantly higher and NO level was lower in patients. Serum homocysteine, 
      ADMA and NO levels found to be correlated among them and with blood pressure. In 
      conclusion, we found that homocysteine and ADMA levels were increased and NO 
      levels decreased in pre-eclampsia.
FAU - Demir, B
AU  - Demir B
AD  - Ergani State Hospital, Department of Obstetrics and Gynecology, Diyarbakir, 
      Turkey. bulentdemirmd@hotmail.com
FAU - Demir, S
AU  - Demir S
FAU - Pasa, S
AU  - Pasa S
FAU - Guven, S
AU  - Guven S
FAU - Atamer, Y
AU  - Atamer Y
FAU - Atamer, A
AU  - Atamer A
FAU - Kocyigit, Y
AU  - Kocyigit Y
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Obstet Gynaecol
JT  - Journal of obstetrics and gynaecology : the journal of the Institute of 
      Obstetrics and Gynaecology
JID - 8309140
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 63CV1GEK3Y (N,N-dimethylarginine)
RN  - 94ZLA3W45F (Arginine)
SB  - IM
MH  - Adult
MH  - Arginine/*analogs & derivatives/blood
MH  - Case-Control Studies
MH  - Female
MH  - Homocysteine/*blood
MH  - Humans
MH  - Nitric Oxide/*blood
MH  - Pre-Eclampsia/*blood
MH  - Pregnancy
MH  - Young Adult
EDAT- 2012/07/12 06:00
MHDA- 2012/12/18 06:00
CRDT- 2012/07/12 06:00
PHST- 2012/07/12 06:00 [entrez]
PHST- 2012/07/12 06:00 [pubmed]
PHST- 2012/12/18 06:00 [medline]
AID - 10.3109/01443615.2012.693985 [doi]
PST - ppublish
SO  - J Obstet Gynaecol. 2012 Aug;32(6):525-8. doi: 10.3109/01443615.2012.693985.