PMID- 22780932
OWN - NLM
STAT- MEDLINE
DCOM- 20130225
LR  - 20181023
IS  - 0253-3766 (Print)
IS  - 0253-3766 (Linking)
VI  - 34
IP  - 2
DP  - 2012 Feb
TI  - [Expression of HMGB1 protein in laryngeal squamous cell carcinoma and its 
      clinical significance].
PG  - 132-6
LID - 10.3760/cma.j.issn.0253-3766.2012.02.011 [doi]
AB  - OBJECTIVE: To evaluate the expression of HMGB1 protein in tissue specimens of 
      laryngeal squamous cell carcinoma (LSCC) and adjacent normal mucosa, and explore 
      the correlation of HMGB1 protein expression with clinicopathologic features and 
      prognosis in LSCC. METHODS: Ninty-three cases of LSCC and 5 cases of adjcent 
      mucosal tissue samples were included in this study. Immunohistochemical staining 
      was performed on paraffin-embedded tissue specimens to examine the HMGB1 protein 
      expression. The data were futher correlated with the clinicopathological features 
      and prognosis of the LSCC patients. RESULTS: The positive rates of HMGB1 
      expression in LSCC specimens was 87.1%, significantly higher than that in the 
      adjcent normal mucosa samples (46.7%, P = 0.001), and its overexpresion was 
      closely correlated with T stage (Chi2 = 10.878, P = 0.004), clinical stage (Chi2 
      = 21.115, P < 0.01), metastasis (Chi2 = 28.298, P < 0.01) and recurrence (Chi2 = 
      14. 923, P = 0.001) in patients with LSCC. Patients with HMGB1 overexpression had 
      both poorer disease-free survival and poorer overall survival compared with that 
      in patients with low HMGB1 expression (Chi2 = 13.815, Chi2 = 11.912; Both P < 
      0.01). Univariate and multivariate Cox regression analyses revealed that HMGBI 
      expression is an independent prognostic factor for patients with LSCC. 
      CONCLUSIONS: The results of this study demonstrate that HMGB1 protein expression 
      is significantly increased in LSCC tissues, and HMGB1 protein overexpression is 
      associated with a poorer prognosis in patients with LSCC. These results suggest 
      that HMGB1 may play a critical role in the initiation and progression of LSCC, 
      implicating HMGB1 may become a valuable marker for the prediction of prognosis in 
      patients with LSCC.
FAU - Liu, Yong
AU  - Liu Y
AD  - Department of Otorhinolaryngology, Xiangya Hospital, Central South University, 
      Changsha Hunan 410008, China.
FAU - Xie, Cong-Liang
AU  - Xie CL
FAU - Qiu, Yuan-Zheng
AU  - Qiu YZ
FAU - Tian, Yong-Quan
AU  - Tian YQ
FAU - Zhang, Xin
AU  - Zhang X
FAU - Huang, Dong-Hai
AU  - Huang DH
FAU - Zhou, Xiao-Juan
AU  - Zhou XJ
FAU - Tan, Ping-Qing
AU  - Tan PQ
FAU - Yu, Chang-Yun
AU  - Yu CY
FAU - Qi, Lin
AU  - Qi L
FAU - Li, Bo
AU  - Li B
FAU - Xiao, Jian-Yun
AU  - Xiao JY
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Zhong Liu Za Zhi
JT  - Zhonghua zhong liu za zhi [Chinese journal of oncology]
JID - 7910681
RN  - 0 (HMGB1 Protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*metabolism/*pathology/surgery
MH  - Disease-Free Survival
MH  - Female
MH  - Follow-Up Studies
MH  - HMGB1 Protein/*metabolism
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/*pathology/surgery
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local
MH  - Neoplasm Staging
MH  - Proportional Hazards Models
MH  - Survival Rate
EDAT- 2012/07/12 06:00
MHDA- 2013/02/26 06:00
CRDT- 2012/07/12 06:00
PHST- 2012/07/12 06:00 [entrez]
PHST- 2012/07/12 06:00 [pubmed]
PHST- 2013/02/26 06:00 [medline]
AID - 10.3760/cma.j.issn.0253-3766.2012.02.011 [doi]
PST - ppublish
SO  - Zhonghua Zhong Liu Za Zhi. 2012 Feb;34(2):132-6. doi: 
      10.3760/cma.j.issn.0253-3766.2012.02.011.