PMID- 22781023
OWN - NLM
STAT- MEDLINE
DCOM- 20130418
LR  - 20131121
IS  - 1476-5640 (Electronic)
IS  - 0954-3007 (Linking)
VI  - 66
IP  - 9
DP  - 2012 Sep
TI  - Evidence for augmented oxidative stress in the subjects with type 1 diabetes and 
      their siblings: a possible preventive role for antioxidants.
PG  - 1054-8
LID - 10.1038/ejcn.2012.81 [doi]
AB  - BACKGROUND/OBJECTIVES: Oxidative stress (OS) is thought to be involved in both 
      development of type 1 diabetes (T1D) and its further complications. In this 
      study, certain biomarkers of OS were compared among the subjects with T1D, their 
      non-diabetic siblings and unrelated healthy controls. SUBJECTS/METHODS: Known 
      cases of T1D from both sexes aged 5-25 years were enrolled in a case-control 
      study (n(1)=60). There were two control groups; non-diabetic siblings (n(2)=60) 
      and unrelated apparently healthy subjects (n(3)=60). Anthropometric, dietary and 
      laboratory assessments were done. RESULTS: There was no significant difference in 
      dietary data among the groups. Total antioxidant capacity was significantly lower 
      in T1D than both related and unrelated controls (1.6 +/- 0.05, 1.7 +/- 0.05 and 1.8 +/- 
      0.06 mmol BSA equivalent/l, respectively, P=0.044). Both T1D subjects and their 
      siblings showed lower glutathione peroxidase (GSH-px) levels (median 
      (interquartile range): 22.2 (28.6), 29.9 (23) and 41.8 (73.6) U/ml, respectively, 
      P=0.006). On the contrary, superoxide dismutase concentrations were significantly 
      higher in T1D group and the siblings than unrelated healthy controls (243 (45.3), 
      157.8 (176.9) and 27.9 (8.7) U/l, respectively, P<0.001). Serum concentrations of 
      GSH correlated with energy intake in the siblings (r=0.521, P<0.001) and 
      unrelated controls (r=0.268, P=0.042) but not in T1D group. The associations 
      remained significant after controlling for blood glucose (r=0.437, P=0.001 and 
      r=0.420, P=0.011, respectively) in both the groups. CONCLUSION: Augmented OS in 
      the siblings may indicate an increased requirement for antioxidants in 
      genetically diabetes-prone subjects.
FAU - Neyestani, T R
AU  - Neyestani TR
AD  - Laboratory of Nutrition Research, National Nutrition and Food Technology Research 
      Institute (NNFTRI), Faculty of Nutrition Sciences and Food Technology, Shahid 
      Beheshti University of Medical Sciences, Tehran, Iran. t.neyestani@nnftri.ac.ir
FAU - Ghandchi, Z
AU  - Ghandchi Z
FAU - Eshraghian, M-R
AU  - Eshraghian MR
FAU - Kalayi, A
AU  - Kalayi A
FAU - Shariatzadeh, N
AU  - Shariatzadeh N
FAU - Houshiarrad, A
AU  - Houshiarrad A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120711
PL  - England
TA  - Eur J Clin Nutr
JT  - European journal of clinical nutrition
JID - 8804070
RN  - 0 (Blood Glucose)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Diabetes Mellitus, Type 1/blood/enzymology/*metabolism
MH  - Female
MH  - Glutathione/blood
MH  - Glutathione Peroxidase/blood
MH  - Humans
MH  - Iran
MH  - Male
MH  - Oxidative Stress/*physiology
MH  - Siblings
MH  - Statistics, Nonparametric
MH  - Superoxide Dismutase/blood
MH  - Young Adult
EDAT- 2012/07/12 06:00
MHDA- 2013/04/20 06:00
CRDT- 2012/07/12 06:00
PHST- 2012/07/12 06:00 [entrez]
PHST- 2012/07/12 06:00 [pubmed]
PHST- 2013/04/20 06:00 [medline]
AID - ejcn201281 [pii]
AID - 10.1038/ejcn.2012.81 [doi]
PST - ppublish
SO  - Eur J Clin Nutr. 2012 Sep;66(9):1054-8. doi: 10.1038/ejcn.2012.81. Epub 2012 Jul 
      11.