PMID- 22781703
OWN - NLM
STAT- MEDLINE
DCOM- 20130409
LR  - 20220310
IS  - 1477-7525 (Electronic)
IS  - 1477-7525 (Linking)
VI  - 10
DP  - 2012 Jul 10
TI  - Linking the Tinnitus Questionnaire and the subjective Clinical Global Impression: 
      which differences are clinically important?
PG  - 79
LID - 10.1186/1477-7525-10-79 [doi]
AB  - BACKGROUND: Development of new tinnitus treatments requires prospective 
      placebo-controlled randomized trials to prove their efficacy. The Tinnitus 
      Questionnaire (TQ) is a validated and commonly used instrument for assessment of 
      tinnitus severity and has been used in many clinical studies. Defining the 
      Minimal Clinically Important Difference (MCID) for TQ changes is an important 
      step to a better interpretation of the clinical relevance of changes observed in 
      clinical trials. In this study we aimed to estimate the minimum change of the TQ 
      score that could be considered clinically relevant. METHODS: 757 patients with 
      chronic tinnitus were pooled from the TRI database and the RESET study. An 
      anchor-based approach using the Clinical Global Impression (CGI) scale and 
      distributional approaches were used to estimate MCID. Receiver Operating 
      Characteristic (ROC) curves were calculated to define optimal TQ change cutoffs 
      discriminating between minimally changed and unchanged subjects. RESULTS: The 
      relationship between TQ change scores and CGI ratings of change was good 
      (r = 0.52, p < 0.05). Mean change scores associated with minimally better and 
      minimally worse CGI categories were -6.65 and +2.72 respectively. According to 
      the ROC method MCID for improvement was -5 points and for deterioration +1 
      points. CONCLUSION: Distribution and anchor-based methods yielded comparable 
      results in identifying MCIDs. DeltaTQ scores of -5 and +1 points were identified as 
      the minimal clinically relevant change for improvement and worsening 
      respectively. The asymmetry of the MCIDs for improvement and worsening may be 
      related to expectation effects.
FAU - Adamchic, Ilya
AU  - Adamchic I
AD  - Institute of Neuroscience and Medicine-Neuromodulation, Research Center Julich, 
      Leo-Brand-Strasse, 52425, Julich, Germany. iadamchic@fz-juelich.de
FAU - Tass, Peter Alexander
AU  - Tass PA
FAU - Langguth, Berthold
AU  - Langguth B
FAU - Hauptmann, Christian
AU  - Hauptmann C
FAU - Koller, Michael
AU  - Koller M
FAU - Schecklmann, Martin
AU  - Schecklmann M
FAU - Zeman, Florian
AU  - Zeman F
FAU - Landgrebe, Michael
AU  - Landgrebe M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20120710
PL  - England
TA  - Health Qual Life Outcomes
JT  - Health and quality of life outcomes
JID - 101153626
SB  - IM
MH  - Female
MH  - Humans
MH  - Male
MH  - *Surveys and Questionnaires
MH  - Tinnitus/*psychology
PMC - PMC3487915
EDAT- 2012/07/12 06:00
MHDA- 2013/04/10 06:00
PMCR- 2012/07/10
CRDT- 2012/07/12 06:00
PHST- 2012/02/08 00:00 [received]
PHST- 2012/07/02 00:00 [accepted]
PHST- 2012/07/12 06:00 [entrez]
PHST- 2012/07/12 06:00 [pubmed]
PHST- 2013/04/10 06:00 [medline]
PHST- 2012/07/10 00:00 [pmc-release]
AID - 1477-7525-10-79 [pii]
AID - 10.1186/1477-7525-10-79 [doi]
PST - epublish
SO  - Health Qual Life Outcomes. 2012 Jul 10;10:79. doi: 10.1186/1477-7525-10-79.