PMID- 22781790
OWN - NLM
STAT- MEDLINE
DCOM- 20130905
LR  - 20120711
IS  - 0253-2727 (Print)
IS  - 0253-2727 (Linking)
VI  - 33
IP  - 5
DP  - 2012 May
TI  - [The impact of HLA high resolution typing mismatching of donor-recipient pairs on 
      outcome of unrelated donor hematopoietic stem cell transplantation].
PG  - 353-7
AB  - OBJECTIVE: To study the impact of various human leukocyte antigen (HLA) high 
      resolution typing mismatching of donor-recipient pairs on prognosis of unrelated 
      donor hematopoietic stem cell transplantation. METHODS: 835 donor-recipient pairs 
      of CMDP data from 2005 to 2010 were analyzed retrospectively. HLA-A, B, C, DRB1 
      and DQB1 typing were performed using SBT, SSOP and SSP methods. The diseases 
      involved in acute myeloid leukemia (AML) (n = 288), acute lymphoid leukemia (ALL) 
      (n = 227), chronic myeloid leukemia (CML) (n = 187), myelodysplastic syndrome 
      (MDS) (n = 52), non-hodgkin's lymphoma(NHL) (n = 25), aplastic anemia(AA) (n = 
      42) and thalassemia (n = 14). Of 835 donor-recipient pairs, 362 were completely 
      matched, 159 had a mismatch for a single allele, 125 had a mismatch for a single 
      antigen, 95 had mismatched for both single allele and single antigen, 29 were 
      mismatched at double allele, 20 at double antigen, 45 at multiple allele and 
      antigen. The follow-up assessment was completed before March 2011. RESULTS: 
      HLA-matched pairs had higher overall survival (OS) than HLA-mismatched pairs 
      (79.83% vs 73.15%), but there was no statistically significant differences (P > 
      0.05). HLA mismatch for a single allele plus a single antigen was a significantly 
      risk factor for OS, disease free survival (DFS) and transplant-related mortality 
      (TRM). The OS from high to low in different diseases were thalassemia, AA, CML, 
      MDS, AML, NHL, and ALL. OS of HLA locus mismatch were DRB1 (94.4%), DQB1 (83.3%), 
      B (75%), A (74.4%) and C (71.4%), respectively. OS of single allele mismatch at 
      HLA locus from high to low were DRB1, C, A, B and DQB1.HLA-A, B, C locus mismatch 
      were statistically significantly associated with lower OS and grade II-IV acute 
      GVHD compared with HLA-matched pairs (P < 0.05). The donor-recipient pairs with 
      HLA-B*15:01/B*15:05, DRB1*12:01/DRB1*12:02, C*04:01/C*03:04, 
      DQB1*03:02/DQB1*03:03 alleles mismatch were given priority. But the 
      donor-recipient pairs with HLA-B*39:01/B*39:05, C*15:02/C*14:02, C*08:01/C*03:04, 
      C*07:02/C*15:02 alleles mismatch were risk factors for influence of OS and aGVHD. 
      CONCLUSION: The high resolution typing for HLA-A, B, C, DRB1, DQB1 can be 
      identified nonpermissive mismatch, which is beneficial for the selection of a 
      suitable donor improves survival on unrelated donor HSCT.
FAU - He, Jun
AU  - He J
AD  - The First Affiliated Hospital of Soochow University, Jiangsu Institute of 
      Hematology, Suzhou, China.
FAU - Xu, Chao
AU  - Xu C
FAU - Wu, Xiao-jin
AU  - Wu XJ
FAU - Bao, Xiao-jing
AU  - Bao XJ
FAU - Qiu, Qiao-cheng
AU  - Qiu QC
FAU - Yuan, Xiao-ni
AU  - Yuan XN
FAU - Li, Yang
AU  - Li Y
FAU - Shen, Hong-jie
AU  - Shen HJ
FAU - Wu, De-pei
AU  - Wu DP
FAU - Hong, Jun-ling
AU  - Hong JL
FAU - Liu, Jing-Hu
AU  - Liu JH
FAU - DU, Hai-ying
AU  - DU HY
FAU - Zhang, Lei
AU  - Zhang L
FAU - DU, Dan
AU  - DU D
FAU - Lu, Jing
AU  - Lu J
FAU - Liu, Jing
AU  - Liu J
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - China
TA  - Zhonghua Xue Ye Xue Za Zhi
JT  - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
JID - 8212398
RN  - 0 (HLA Antigens)
SB  - IM
MH  - HLA Antigens/genetics/*immunology
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Histocompatibility Testing
MH  - Humans
MH  - Leukemia, Myeloid, Acute/immunology/surgery
MH  - Lymphoma, Non-Hodgkin/immunology/surgery
MH  - Myelodysplastic Syndromes/immunology/surgery
MH  - Prognosis
MH  - Retrospective Studies
MH  - *Unrelated Donors
EDAT- 2012/07/12 06:00
MHDA- 2013/09/06 06:00
CRDT- 2012/07/12 06:00
PHST- 2012/07/12 06:00 [entrez]
PHST- 2012/07/12 06:00 [pubmed]
PHST- 2013/09/06 06:00 [medline]
PST - ppublish
SO  - Zhonghua Xue Ye Xue Za Zhi. 2012 May;33(5):353-7.