PMID- 22781888
OWN - NLM
STAT- MEDLINE
DCOM- 20130314
LR  - 20191210
IS  - 0578-1426 (Print)
IS  - 0578-1426 (Linking)
VI  - 51
IP  - 3
DP  - 2012 Mar
TI  - [Etiological analysis of fever in the first 24 hours following allogeneic 
      peripheral stem cell transfusion].
PG  - 179-83
AB  - OBJECTIVE: To investigate the incidence and pathogenesis of fever within the 
      first 24 hours following allogeneic peripheral stem cell transfusion and to 
      analyze the associated risk factors. METHODS: Totally 114 patients received 
      allogeneic hematopoietic stem cell transplantation (allo-HSCT) between October 
      2009 and August 2010 were enrolled and clinical data of febrile patients within 
      24 hours following peripheral stem cell transfusion were retrospectively 
      analyzed. Multivariate logistic regression analysis was performed to identify the 
      risk factors for transfusion related fever. RESULTS: Thirty-two (28.1%) out of 
      the 114 patients had a fever within 24 hours after allo-HSCT. All of them were 
      human leukocyte antigen (HLA) mismatch transplantation. The median time of the 
      temperature elevated was 2.5 (0 - 18.0) hours after the infusion with a median 
      time of the peak of 7.8 (3.5 - 23.0) hours after the infusion. Fever was 
      attributed to definite infection in 6 patients and no definite infection in the 
      remaining 26 patients. None of them were hemolytic, which was attributed to 
      transfusion related fever. Multivariate analysis showed that female donor and 
      high count of peripheral leukocyte of donor peripheral blood were significant 
      predictors for transfusion related fever. CONCLUSIONS: Most of post-infusion 
      fever within 24 hours after HLA mismatch related transplantation has no 
      identifiable infectious focus. The risk factors for transfusion related fever are 
      female donor and high number of peripheral leukocyte of donor blood.
FAU - Chen, Yao
AU  - Chen Y
AD  - Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell 
      Transplantation, People's Hospital, Peking University, Beijing 100044, China.
FAU - Huang, Xiao-jun
AU  - Huang XJ
FAU - Wang, Feng-rong
AU  - Wang FR
FAU - Yan, Chen-hua
AU  - Yan CH
FAU - Wang, Yu
AU  - Wang Y
FAU - Zhang, Yuan-yuan
AU  - Zhang YY
FAU - Han, Wei
AU  - Han W
FAU - Chen, Huan
AU  - Chen H
FAU - Liu, Dai-hong
AU  - Liu DH
FAU - Liu, Kai-yan
AU  - Liu KY
FAU - Xu, Lan-Ping
AU  - Xu LP
LA  - chi
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - China
TA  - Zhonghua Nei Ke Za Zhi
JT  - Zhonghua nei ke za zhi
JID - 16210490R
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Fever/*etiology
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects
MH  - Humans
MH  - Infections/etiology
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Transfusion Reaction
MH  - Transplantation, Homologous/adverse effects
MH  - Young Adult
EDAT- 2012/07/12 06:00
MHDA- 2013/03/15 06:00
CRDT- 2012/07/12 06:00
PHST- 2012/07/12 06:00 [entrez]
PHST- 2012/07/12 06:00 [pubmed]
PHST- 2013/03/15 06:00 [medline]
PST - ppublish
SO  - Zhonghua Nei Ke Za Zhi. 2012 Mar;51(3):179-83.