PMID- 22783385
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240315
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 3
IP  - 5
DP  - 2012 May
TI  - A chronic myeloid leukemia case with a unique variant Philadelphia translocation: 
      t(9;22;21)(q34;q11;p12).
PG  - 1027-1029
AB  - The so-called Philadelphia (Ph) chromosome is present in more than 90% of chronic 
      myeloid leukemia (CML) patients. Approximately, 5-10% of these patients show 
      complex translocations involving a third chromosome in addition to chromosomes 9 
      and 22. Since at present the majority of CML cases are treated with imatinib, 
      variant rearrangements do not exhibit specific prognostic significance. However, 
      events of therapy resistance remain to be studied. In this study, we report a 
      unique case of CML exhibiting an uncommon t(21;22)(p12;q11). This translocation 
      has been characterized by fluorescence in situ hybridization (FISH) and 
      array-proven multicolor banding (aMCB). Using specific probes for the BCR and ABL 
      genes, results of FISH showed a three-way variant Philadelphia translocation 
      (9;22;21)(q34;q11;p12) with a BCR/ABL fusion residing on the der(22) and the 
      3'BCR region translocated on the short arm of the derivative chromosome 21. In 
      addition, the aMCB technique is significant in the detection of the breakpoints 
      of genetic changes. The underlying mechanisms and prognostic significance of 
      these changes are discussed.
FAU - Al-Achkar, Walid
AU  - Al-Achkar W
AD  - Molecular Biology and Biotechnology Department, Human Genetics Division, Atomic 
      Energy Commission, Damascus, Syria.
FAU - Wafa, Abdulsamad
AU  - Wafa A
FAU - Moassass, Faten
AU  - Moassass F
FAU - Liehr, Thomas
AU  - Liehr T
LA  - eng
PT  - Journal Article
DEP - 20120228
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC3389665
EDAT- 2012/07/12 06:00
MHDA- 2012/07/12 06:01
PMCR- 2012/02/28
CRDT- 2012/07/12 06:00
PHST- 2011/05/26 00:00 [received]
PHST- 2011/07/25 00:00 [accepted]
PHST- 2012/07/12 06:00 [entrez]
PHST- 2012/07/12 06:00 [pubmed]
PHST- 2012/07/12 06:01 [medline]
PHST- 2012/02/28 00:00 [pmc-release]
AID - ol-03-05-1027 [pii]
AID - 10.3892/ol.2012.623 [doi]
PST - ppublish
SO  - Oncol Lett. 2012 May;3(5):1027-1029. doi: 10.3892/ol.2012.623. Epub 2012 Feb 28.