PMID- 22784102
OWN - NLM
STAT- MEDLINE
DCOM- 20130604
LR  - 20150623
IS  - 1444-0938 (Electronic)
IS  - 0816-4622 (Linking)
VI  - 96
IP  - 1
DP  - 2013 Jan
TI  - Spectral domain optical coherence tomography and angiographic findings in 
      multifocal posterior pigment epitheliopathy treated with low-fluence photodynamic 
      therapy.
PG  - 126-9
LID - 10.1111/j.1444-0938.2012.00767.x [doi]
AB  - PURPOSE: The aim was to evaluate spectral domain optical coherence tomographic 
      (SD-OCT), fluorescein angiography (FA) and indocyanine green angiography (ICGA) 
      findings in multifocal posterior pigment epitheliopathy (MPPE) treated with 
      low-fluence photodynamic therapy. METHODS: A 54-year-old Japanese man with serous 
      retinal detachment (SRD) and pigment epithelial detachment (PED) due to 
      multifocal posterior pigment epitheliopathy in the right eye was managed with 
      ICGA-guided low-fluence photodynamic therapy. Outcome measures included visual 
      acuity, SD-OCT appearance and FA and ICGA findings. RESULTS: The patient received 
      low-fluence photodynamic therapy within two weeks after the onset of symptoms. 
      After treatment, serous retinal detachment and PED resolved in two weeks. Visual 
      acuity returned to 1.0, the external limiting membrane and the photoreceptor 
      inner and outer segment junction integrity were restored and the subfoveal 
      choroidal thickness was greatly reduced. There has been no recurrence in six 
      months. FA demonstrated stoppage of leakage and ICGA showed a marked decrease of 
      choroidal venous dilation and vascular hyperpermeability. CONCLUSION: To our 
      knowledge, this is the first report to examine photoreceptor integrity, foveal 
      choroidal thickness and choroidal circulation in a case of MPPE treated with 
      low-fluence photodynamic therapy. Early application of the photodynamic therapy 
      led to restoration of photoreceptor integrity with improvement of choroidal 
      thickness and circulation.
CI  - (c) 2012 The Authors. Clinical and Experimental Optometry (c) 2012 Optometrists 
      Association Australia.
FAU - Kuroyanagi, Kana
AU  - Kuroyanagi K
AD  - Department of Ophthalmology, Jikei University School of Medicine, Tokyo, Japan. 
      tstmski@jikei.ac.jp
FAU - Sakai, Tsutomu
AU  - Sakai T
FAU - Kasai, Kozue
AU  - Kasai K
FAU - Tsuneoka, Hiroshi
AU  - Tsuneoka H
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20120711
PL  - United States
TA  - Clin Exp Optom
JT  - Clinical & experimental optometry
JID - 8703442
RN  - 0 (Photosensitizing Agents)
SB  - IM
MH  - Central Serous Chorioretinopathy
MH  - Choroid/pathology
MH  - Dose-Response Relationship, Drug
MH  - Fluorescein Angiography/*methods
MH  - Follow-Up Studies
MH  - Fundus Oculi
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Photochemotherapy/*methods
MH  - Photosensitizing Agents/*administration & dosage
MH  - Retinal Pigment Epithelium/pathology
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Acuity
EDAT- 2012/07/13 06:00
MHDA- 2013/06/05 06:00
CRDT- 2012/07/13 06:00
PHST- 2011/12/13 00:00 [received]
PHST- 2012/03/04 00:00 [revised]
PHST- 2012/04/17 00:00 [accepted]
PHST- 2012/07/13 06:00 [entrez]
PHST- 2012/07/13 06:00 [pubmed]
PHST- 2013/06/05 06:00 [medline]
AID - 10.1111/j.1444-0938.2012.00767.x [doi]
PST - ppublish
SO  - Clin Exp Optom. 2013 Jan;96(1):126-9. doi: 10.1111/j.1444-0938.2012.00767.x. Epub 
      2012 Jul 11.