PMID- 22784256
OWN - NLM
STAT- MEDLINE
DCOM- 20131029
LR  - 20191210
IS  - 1369-1600 (Electronic)
IS  - 1355-6215 (Linking)
VI  - 18
IP  - 4
DP  - 2013 Jul
TI  - Contribution of impulsivity and novelty-seeking to the acquisition and 
      maintenance of MDMA self-administration.
PG  - 654-64
LID - 10.1111/j.1369-1600.2012.00477.x [doi]
AB  - It has been suggested that the response to novelty and impulsivity predict the 
      latency to acquisition and maintenance of drug self-administration, respectively. 
      The aim of this study was to examine the relationship between these two traits 
      and (1) the latency to acquisition and (2) maintenance (drug-seeking) of 
      3,4-methylenedioxymethamphetamine (MDMA) self -administration. Impulsivity, 
      measured as premature responding on the five-choice serial reaction time task 
      (5-CSRTT), and novelty-seeking, measured as the locomotor response in a novel 
      environment, were measured prior to self-administration. Latency to acquisition 
      was determined as the number of test sessions required to self-administer an 
      initial criterion of 90 infusions of 1.0 mg/kg/infusion, as well as an additional 
      150 infusions of 0.5 mg/kg/infusion MDMA. For some rats, the ability of MDMA [0, 
      5.0 or 10.0 mg/kg, intraperitoneal (IP)] to produce drug-seeking was subsequently 
      measured, and for others, impulsivity was again measured following 
      self-administration. Novelty-seeking was not significantly correlated with either 
      the acquisition or drug-seeking measures of MDMA self-administration. Impulsivity 
      was not significantly correlated with the latency to acquire self-administration 
      of MDMA, but was significantly and positively correlated with the magnitude of 
      MDMA-produced drug-seeking. Furthermore, MDMA self-administration produced a 
      number of notable, but transient, deficits in the 5-CSRTT; there was an increase 
      in omission rate and a delayed increase in premature responses in particular. 
      These findings suggest that impulsivity, but not sensation seeking, might be a 
      risk factor for the development of compulsive drug-seeking following withdrawal 
      from MDMA self-administration.
CI  - (c) 2012 The Authors, Addiction Biology (c) 2012 Society for the Study of Addiction.
FAU - Bird, Judith
AU  - Bird J
AD  - School of Psychology, Victoria University of Wellington, New Zealand.
FAU - Schenk, Susan
AU  - Schenk S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120711
PL  - United States
TA  - Addict Biol
JT  - Addiction biology
JID - 9604935
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Amphetamine-Related Disorders/physiopathology/*psychology
MH  - Analysis of Variance
MH  - Animals
MH  - Disease Models, Animal
MH  - Drug-Seeking Behavior/drug effects/*physiology
MH  - Exploratory Behavior
MH  - Hallucinogens/*administration & dosage/pharmacology
MH  - Humans
MH  - Impulsive Behavior
MH  - Linear Models
MH  - Locomotion/physiology
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reaction Time/drug effects/physiology
MH  - Reinforcement, Psychology
MH  - Self Administration/psychology
MH  - Time Factors
EDAT- 2012/07/13 06:00
MHDA- 2013/10/30 06:00
CRDT- 2012/07/13 06:00
PHST- 2012/07/13 06:00 [entrez]
PHST- 2012/07/13 06:00 [pubmed]
PHST- 2013/10/30 06:00 [medline]
AID - 10.1111/j.1369-1600.2012.00477.x [doi]
PST - ppublish
SO  - Addict Biol. 2013 Jul;18(4):654-64. doi: 10.1111/j.1369-1600.2012.00477.x. Epub 
      2012 Jul 11.