PMID- 22784283 OWN - NLM STAT- MEDLINE DCOM- 20160423 LR - 20190402 IS - 0304-4920 (Print) IS - 0304-4920 (Linking) VI - 55 IP - 3 DP - 2012 Jun 30 TI - "Regulation of the intracerebroventricular administration of brain-derived neurotrophic factor on baroreflex function and insulin sensitivity in rats". PG - 184-91 LID - CJP.2012.BAA015 [pii] LID - 10.4077/CJP.2012.BAA015 [doi] AB - "In addition to its well-established neurotrophic effects, brain-derived neurotrophic factor (BDNF) has also been shown to regulate glucose metabolism. The present study was conducted to determine whether BDNF has effects on baroreflex sensitivity (BRS) and whole-body insulin sensitivity through modulation of autonomic nervous function in normal rats. Male Sprague-Dawley rats were treated with intracerebroventricular BDNF (20 mug per rat, 10mul; BDNF) or artificial cerebrospinal fluid (10 mul; control) at an infusion rate of 1 mul/min in conscious state. The whole-body insulin sensitivity was determined by the euglycemic hyperinsulinemic clamp technique. BRS in response to phenylephrine (PE-BRS) or sodium nitroprusside (NP-BRS) was assessed using linear regression analysis. The sympathetic and parasympathetic influences on BRS were investigated by pharmacological autonomic blockade. When compared to the control rats, blood glucose levels were slightly but significantly decreased in BDNF-treated rats. However, plasma insulin levels were reduced by about 30%. The whole-body insulin sensitivity was increased in BDNF-treated rats. In addition, blood pressure was increased but heart rate remained unchanged after BDNF treatment. Enhanced PE-BRS was also observed in the BDNF-treated rats, which was attributed to the abnormal parasympathetic activation as revealed by the results of the pharmacological blockade study with methylatropine. Results of the present demonstrate that central BDNF plays an important role in the regulation of whole-body insulin sensitivity and baroreflex function. The data indicate that the alteration of autonomic nervous function may play a role in the effects of BDNF." FAU - Wang, Ming-Fu AU - Wang MF AD - Department of Food and Nutrition, Providence University, Taichung 43301, Taiwan, Republic of China. FAU - Chan, Yin-Ching AU - Chan YC FAU - Lee, Hsu-Tung AU - Lee HT FAU - Hong, Ling-Zong AU - Hong LZ LA - eng PT - Journal Article PL - India TA - Chin J Physiol JT - The Chinese journal of physiology JID - 7804502 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Animals MH - *Baroreflex MH - Blood Pressure MH - Brain-Derived Neurotrophic Factor MH - Heart Rate MH - *Insulin Resistance MH - Rats MH - Rats, Sprague-Dawley EDAT- 2012/07/13 06:00 MHDA- 2016/04/24 06:00 CRDT- 2012/07/13 06:00 PHST- 2012/07/13 06:00 [entrez] PHST- 2012/07/13 06:00 [pubmed] PHST- 2016/04/24 06:00 [medline] AID - CJP.2012.BAA015 [pii] AID - 10.4077/CJP.2012.BAA015 [doi] PST - ppublish SO - Chin J Physiol. 2012 Jun 30;55(3):184-91. doi: 10.4077/CJP.2012.BAA015.