PMID- 2278990
OWN - NLM
STAT- MEDLINE
DCOM- 19910308
LR  - 20190510
IS  - 0953-8178 (Print)
IS  - 0953-8178 (Linking)
VI  - 2
IP  - 4
DP  - 1990
TI  - Effect of Gm allotypes on IgG2 antibody responses and IgG2 concentrations in 
      children and adults.
PG  - 317-22
AB  - Earlier studies have suggested that in adults the n-positive allele of the human 
      IgG2 gene is more productive than the n-negative allele. This superiority was 
      seen to be manifested in IgG2 antibody responses to polysaccharides, in the 
      higher serum concentration of total IgG2 in the n/n than in -/- individuals, and 
      in the higher concentration of n-positive than n-negative IgG2 in heterozygotes. 
      The present study shows that in 1- or 2-year-old children, the concentration of 
      IgG2 was independent of allotype G2m(n), and both alleles of a heterozygote 
      contributed an average of one-half of the total IgG2. On the other hand, the 
      superiority of the n-positive allele was also seen in young children in IgG2 
      antibody responses induced by the Haemophilus influenzae type b polysaccharide 
      (Hib). The effect of allotype n on antibody responses was evident only when the 
      immunogen was the Hib polysaccharide. When the immunogen was a conjugate of Hib 
      and diphtheria toxoid, the IgG2 antibody responses of n-positive and n-negative 
      vaccinated individuals were almost equal, both in adults and in children.
FAU - Sarvas, H
AU  - Sarvas H
AD  - Department of Bacteriology and Immunology, University of Helsinki, Finland.
FAU - Rautonen, N
AU  - Rautonen N
FAU - Kayhty, H
AU  - Kayhty H
FAU - Kallio, M
AU  - Kallio M
FAU - Makela, O
AU  - Makela O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int Immunol
JT  - International immunology
JID - 8916182
RN  - 0 (Bacterial Vaccines)
RN  - 0 (Diphtheria Toxoid)
RN  - 0 (Haemophilus Vaccines)
RN  - 0 (Haemophilus influenzae type b polysaccharide vaccine)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin Gm Allotypes)
RN  - 0 (Polysaccharides, Bacterial)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Alleles
MH  - Bacterial Capsules
MH  - Bacterial Vaccines/immunology
MH  - Child, Preschool
MH  - Diphtheria Toxoid/immunology
MH  - *Haemophilus Vaccines
MH  - Haemophilus influenzae/immunology
MH  - Heterozygote
MH  - Humans
MH  - Immunoglobulin G/*biosynthesis/genetics/metabolism
MH  - *Immunoglobulin Gm Allotypes/genetics
MH  - Infant
MH  - Polysaccharides, Bacterial/immunology
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
AID - 10.1093/intimm/2.4.317 [doi]
PST - ppublish
SO  - Int Immunol. 1990;2(4):317-22. doi: 10.1093/intimm/2.4.317.