PMID- 22790078
OWN - NLM
STAT- MEDLINE
DCOM- 20130423
LR  - 20220309
IS  - 1531-7013 (Electronic)
IS  - 1087-2418 (Linking)
VI  - 17
IP  - 4
DP  - 2012 Aug
TI  - Histocompatibility considerations for kidney paired donor exchange programs.
PG  - 427-32
LID - 10.1097/MOT.0b013e3283556ff2 [doi]
AB  - PURPOSE OF REVIEW: To highlight the role of histocompatibility testing in kidney 
      paired donor (KPD) exchange programs as well as the new technological advances 
      that may have an effect on KPD. RECENT FINDINGS: Technological advances in human 
      leukocyte antigen (HLA) antibody identification using the Luminex single-antigen 
      bead multiplexing platform have facilitated virtual cross-matching and the 
      ability to accurately match donor/recipient pairs through KPD. A knowledge of the 
      limitations of this assay is the key to proper interpretation of the data and 
      maximization of this new technology. Novel assays such as C1q and Ig subclass 
      identification may be useful in further determining which HLA antibodies are 
      clinically relevant. SUMMARY: KPD is an established method for increasing access 
      to transplantation for patients with incompatible live donors. Advances in 
      histocompatibility testing have played a role in the success of KPD.
FAU - Murphey, Cathi L
AU  - Murphey CL
AD  - Southwest Immunodiagnostics Inc., San Antonio, Texas 78229, USA. 
      cathi.murphey@swid-id.com
FAU - Bingaman, Adam W
AU  - Bingaman AW
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Organ Transplant
JT  - Current opinion in organ transplantation
JID - 9717388
RN  - 0 (Antibodies)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Antibodies/analysis
MH  - Directed Tissue Donation
MH  - HLA Antigens/analysis/immunology
MH  - Histocompatibility/immunology
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Kidney/immunology
MH  - *Kidney Transplantation/immunology
MH  - *Tissue and Organ Procurement
EDAT- 2012/07/14 06:00
MHDA- 2013/04/24 06:00
CRDT- 2012/07/14 06:00
PHST- 2012/07/14 06:00 [entrez]
PHST- 2012/07/14 06:00 [pubmed]
PHST- 2013/04/24 06:00 [medline]
AID - 00075200-201208000-00017 [pii]
AID - 10.1097/MOT.0b013e3283556ff2 [doi]
PST - ppublish
SO  - Curr Opin Organ Transplant. 2012 Aug;17(4):427-32. doi: 
      10.1097/MOT.0b013e3283556ff2.