PMID- 22791981
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20220408
IS  - 1177-889X (Electronic)
IS  - 1177-889X (Linking)
VI  - 6
DP  - 2012
TI  - Osteoporosis and type 2 diabetes mellitus: what do we know, and what we can do?
PG  - 435-48
LID - 10.2147/PPA.S32745 [doi]
AB  - Diabetes mellitus (DM) is a pandemic and chronic metabolic disorder with 
      substantial morbidity and mortality. In addition, osteoporosis (OP) is a silent 
      disease with a harmful impact on morbidity and mortality. Therefore, this 
      systematic review focuses on the relationship between OP and type 2 diabetes 
      mellitus (T2DM). Systematic reviews of full-length articles published in English 
      from January 1950 to October 2010 were identified in PubMed and other available 
      electronic databases on the Universiti Sains Malaysia Library Database. The 
      following keywords were used for the search: T2DM, OP, bone mass, skeletal. 
      Studies of more than 50 patients with T2DM were included. Forty-seven studies 
      were identified. The majority of articles (26) showed increased bone mineral 
      density (BMD), while 13 articles revealed decreased BMD; moreover, eight articles 
      revealed normal or no difference in bone mass. There were conflicting results 
      concerning the influence of T2DM on BMD in association with gender, glycemic 
      control, and body mass index. However, patients with T2DM display an increased 
      fracture risk despite a higher BMD, which is mainly attributable to the increased 
      risk of falling. As a conclusion, screening, identification, and prevention of 
      potential risk factors for OP in T2DM patients are crucial and important in terms 
      of preserving a good quality of life in diabetic patients and decreasing the risk 
      of fracture. Patients with T2DM may additionally benefit from early visual 
      assessment, regular exercise to improve muscle strength and balance, and specific 
      measures for preventing falls. Patient education about an adequate calcium and 
      vitamin D intake and regular exercise is important for improving muscle strength 
      and balance. Furthermore, adequate glycemic control and the prevention of 
      diabetic complications are the starting point of therapy in diabetic patients.
FAU - Abdulameer, Shaymaa Abdalwahed
AU  - Abdulameer SA
AD  - School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.
FAU - Sulaiman, Syed Azhar Syed
AU  - Sulaiman SA
FAU - Hassali, Mohamed Azmi Ahmad
AU  - Hassali MA
FAU - Subramaniam, Karuppiah
AU  - Subramaniam K
FAU - Sahib, Mohanad Naji
AU  - Sahib MN
LA  - eng
PT  - Journal Article
DEP - 20120611
PL  - New Zealand
TA  - Patient Prefer Adherence
JT  - Patient preference and adherence
JID - 101475748
PMC - PMC3393120
OTO - NOTNLM
OT  - bone
OT  - diabetes
OT  - osteopenia
OT  - osteoporosis
OT  - skeletal
EDAT- 2012/07/14 06:00
MHDA- 2012/07/14 06:01
PMCR- 2012/06/11
CRDT- 2012/07/14 06:00
PHST- 2012/07/14 06:00 [entrez]
PHST- 2012/07/14 06:00 [pubmed]
PHST- 2012/07/14 06:01 [medline]
PHST- 2012/06/11 00:00 [pmc-release]
AID - ppa-6-435 [pii]
AID - 10.2147/PPA.S32745 [doi]
PST - ppublish
SO  - Patient Prefer Adherence. 2012;6:435-48. doi: 10.2147/PPA.S32745. Epub 2012 Jun 
      11.