PMID- 2279305
OWN - NLM
STAT- MEDLINE
DCOM- 19910308
LR  - 20160818
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 19
IP  - 3
DP  - 1990 Sep
TI  - [Pathohistology of progressive muscular dystrophy and the relationship between 
      necrotic and regenerative fibers].
PG  - 172-4
AB  - Enzyme histochemistry and acridine orange (AO) fluorescence techniques were used 
      for studying muscle biopsy specimens of progressive muscular dystrophy in 75 
      cases. Five characteristic pathologic patterns for diagnosis were summarized. The 
      level of serum CPK was be used as a marker for judging necrotic fibers. The 
      result of AO staining showed that the number of regenerating IIc type fibers in 
      DMD increased by 5-20%. This indicates that the numbers of the IIc type fibers 
      are also related to necrotic fibers. The authors consider that the regenerative 
      course is a compensatory repair reaction on necrotic fibers. But clinically, the 
      speed of necrosis development is much higher than that of regeneration. Thus, 
      enhancing the synthesis of proteins and promoting the capacity of regeneration 
      should be considered as a new approach to effective therapy for DMD patients.
FAU - Chen, B F
AU  - Chen BF
AD  - Department of Pathology, Fujian Medical College.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
RN  - EC 2.7.3.2 (Creatine Kinase)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Creatine Kinase/blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Muscles/pathology
MH  - Muscular Dystrophies/enzymology/*pathology
MH  - Necrosis
MH  - Regeneration
EDAT- 1990/09/01 00:00
MHDA- 1990/09/01 00:01
CRDT- 1990/09/01 00:00
PHST- 1990/09/01 00:00 [pubmed]
PHST- 1990/09/01 00:01 [medline]
PHST- 1990/09/01 00:00 [entrez]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 1990 Sep;19(3):172-4.