PMID- 22795648
OWN - NLM
STAT- MEDLINE
DCOM- 20130722
LR  - 20121112
IS  - 1878-3279 (Electronic)
IS  - 0171-2985 (Linking)
VI  - 217
IP  - 12
DP  - 2012 Dec
TI  - Lymphotoxin-beta receptor expression and its related signaling pathways govern 
      dendritic cell homeostasis and function.
PG  - 1250-8
LID - S0171-2985(12)00150-7 [pii]
LID - 10.1016/j.imbio.2012.06.010 [doi]
AB  - Dendritic cells (DCs) play a fundamental function, either positive or 
      detrimental, in regulating immune responses. Numerous specialized DC subsets 
      exist in different organs. However, the trophic factors regulating their origin, 
      location, homeostasis and functions remains to be fully understood. Recent 
      evidence indicates that signaling via the lymphotoxin beta receptor (LTbetaR) can 
      function as a trophic signaling system for specific DCs. LTbetaR is part of a 
      complex signaling network that provides both positive and inhibitory signals to 
      DC subsets. In this review, we focus on the role of LTbetaR expressed in DC subsets 
      and its associated signaling pathways that regulate DC homeostasis and function. 
      Therapeutically targeting the LTbetaR signaling pathway could support the 
      development of a beneficial immune response for the host.
CI  - Copyright (c) 2012 Elsevier GmbH. All rights reserved.
FAU - De Trez, Carl
AU  - De Trez C
AD  - VIB Department of Structural Biology, Laboratory of Cellular and Molecular 
      Immunology, Vrij Universiteit Brussel (VUB), Building E8.01, Pleinlaan 2, B-1050 
      Brussels, Belgium. carldetrez@yahoo.fr
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120626
PL  - Netherlands
TA  - Immunobiology
JT  - Immunobiology
JID - 8002742
RN  - 0 (Lymphotoxin beta Receptor)
SB  - IM
MH  - Animals
MH  - Dendritic Cells/immunology/metabolism/*physiology
MH  - Homeostasis/physiology
MH  - Lymphotoxin beta Receptor/*biosynthesis/*genetics/immunology/metabolism
MH  - Signal Transduction/genetics/*immunology/physiology
EDAT- 2012/07/17 06:00
MHDA- 2013/07/23 06:00
CRDT- 2012/07/17 06:00
PHST- 2012/04/23 00:00 [received]
PHST- 2012/06/20 00:00 [accepted]
PHST- 2012/07/17 06:00 [entrez]
PHST- 2012/07/17 06:00 [pubmed]
PHST- 2013/07/23 06:00 [medline]
AID - S0171-2985(12)00150-7 [pii]
AID - 10.1016/j.imbio.2012.06.010 [doi]
PST - ppublish
SO  - Immunobiology. 2012 Dec;217(12):1250-8. doi: 10.1016/j.imbio.2012.06.010. Epub 
      2012 Jun 26.