PMID- 22795756
OWN - NLM
STAT- MEDLINE
DCOM- 20130208
LR  - 20181201
IS  - 1879-3479 (Electronic)
IS  - 0020-7292 (Linking)
VI  - 119
IP  - 1
DP  - 2012 Oct
TI  - Fetal and maternal hemodynamics in acute malaria during pregnancy.
PG  - 66-9
LID - 10.1016/j.ijgo.2012.04.024 [doi]
AB  - OBJECTIVE: To measure maternal and fetal hemodynamics during acute malaria in 
      pregnancy. METHODS: Time courses of maternal heart rate (MHR), maternal blood 
      pressure (BP), and fetal heart rate (FHR) were performed until 56 days after 
      initiation of anti-malarial treatment with artemether-lumefantrine. Women with 
      malaria were hospitalized for at least 3 days until recovery. RESULTS: Mean 
      baseline characteristics of pregnant women with malaria (n=38) versus pregnant 
      women without malaria (n=39) were as follows: gestational age (28.8 vs 24.6 
      weeks; P=0.006); maximum FHR (165.3 vs 158.3 beats per minute [bpm]; P=0.054); 
      minimum FHR (137.6 vs 128.7 bpm; P=0.016); mean BP (74.7 vs 80.9 mm Hg; P=0.001); 
      pulse pressure (40.3 vs 42.1mm Hg; P=0.300); and MHR (107.4 vs 81.3 bpm; 
      P<0.001). The geometric mean parasite count was 13 795 per muL. Complete time 
      courses were collected from a subgroup of participants. For women with malaria, 
      maternal body temperature and BP normalized within 24 hours and after 72 hours, 
      respectively. The MHR among pregnant women without malaria showed a physiologic 
      increase during pregnancy of approximately 7 bpm between days 0 and 56. The mean 
      FHR among women with malaria normalized after 72 hours. CONCLUSION: Acute malaria 
      induces maternal and fetal hemodynamic changes.
CI  - Copyright (c) 2012 International Federation of Gynecology and Obstetrics. Published 
      by Elsevier Ireland Ltd. All rights reserved.
FAU - Rulisa, Stephen
AU  - Rulisa S
AD  - National University of Rwanda, University Teaching Hospital of Kigali, Kigali, 
      Rwanda. s.rulisa@gmail.com
FAU - Kaligirwa, Nadine
AU  - Kaligirwa N
FAU - Agaba, Steven
AU  - Agaba S
FAU - Karangayire, Placide
AU  - Karangayire P
FAU - Mens, Petra F
AU  - Mens PF
FAU - de Vries, Peter J
AU  - de Vries PJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120712
PL  - United States
TA  - Int J Gynaecol Obstet
JT  - International journal of gynaecology and obstetrics: the official organ of the 
      International Federation of Gynaecology and Obstetrics
JID - 0210174
RN  - 0 (Antimalarials)
RN  - 0 (Artemether, Lumefantrine Drug Combination)
RN  - 0 (Artemisinins)
RN  - 0 (Drug Combinations)
RN  - 0 (Ethanolamines)
RN  - 0 (Fluorenes)
RN  - Acute malaria
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antimalarials/therapeutic use
MH  - Artemether, Lumefantrine Drug Combination
MH  - Artemisinins/therapeutic use
MH  - Body Temperature/drug effects
MH  - Drug Combinations
MH  - Ethanolamines/therapeutic use
MH  - Female
MH  - Fluorenes/therapeutic use
MH  - Hemodynamics/drug effects/*physiology
MH  - Humans
MH  - Malaria/drug therapy/*physiopathology
MH  - Malaria, Falciparum/drug therapy/*physiopathology
MH  - Plasmodium falciparum/drug effects/isolation & purification
MH  - Pregnancy
MH  - Pregnancy Complications, Parasitic/drug therapy/*physiopathology
MH  - Pregnancy Trimester, Second
MH  - Pregnancy Trimester, Third
MH  - Young Adult
EDAT- 2012/07/17 06:00
MHDA- 2013/02/09 06:00
CRDT- 2012/07/17 06:00
PHST- 2011/12/20 00:00 [received]
PHST- 2012/04/24 00:00 [revised]
PHST- 2012/06/21 00:00 [accepted]
PHST- 2012/07/17 06:00 [entrez]
PHST- 2012/07/17 06:00 [pubmed]
PHST- 2013/02/09 06:00 [medline]
AID - S0020-7292(12)00327-X [pii]
AID - 10.1016/j.ijgo.2012.04.024 [doi]
PST - ppublish
SO  - Int J Gynaecol Obstet. 2012 Oct;119(1):66-9. doi: 10.1016/j.ijgo.2012.04.024. 
      Epub 2012 Jul 12.