PMID- 22795795
OWN - NLM
STAT- MEDLINE
DCOM- 20130401
LR  - 20120827
IS  - 1873-281X (Electronic)
IS  - 1472-9792 (Linking)
VI  - 92
IP  - 5
DP  - 2012 Sep
TI  - AIDS associated tuberculosis: a catastrophic collision to evade the host immune 
      system.
PG  - 384-7
LID - 10.1016/j.tube.2012.05.006 [doi]
AB  - Human immunodeficiency virus (HIV) is a causative agent of AIDS while 
      Mycobacterium tuberculosis causes human tuberculosis, independently. HIV and M. 
      tuberculosis co-infection is an intriguing immunopathological phenomenon. The 
      effect is not simply an additive but far more than that. This review gives an 
      account of how various host and pathogen specific factors interplay to make this 
      co-infection one of the worst co-infection, rightly named as medical "double 
      jeopardy". We have attempted to recount some of the immune mechanisms how both 
      these pathogens disturb the balance of host immune system resulting into defects 
      in the host phagocytic response, leading to apoptosis and chemokine 
      dysregulation. The HIV provides protected shelter to the M. tuberculosis and M. 
      tuberculosis provides conducive atmosphere through the interplay of various 
      chemokines. We also touch upon the treatment associated complications like Immune 
      reconstitution inflammatory syndrome (IRIS) these patients face.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Munawwar, Arshi
AU  - Munawwar A
AD  - Division of Clinical Microbiology, All India Institute of Medical Sciences, New 
      Delhi 110029, India.
FAU - Singh, Sarman
AU  - Singh S
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120712
PL  - Scotland
TA  - Tuberculosis (Edinb)
JT  - Tuberculosis (Edinburgh, Scotland)
JID - 100971555
SB  - IM
MH  - AIDS-Related Opportunistic Infections/drug therapy/*immunology/physiopathology
MH  - Acquired Immunodeficiency Syndrome/drug therapy/*immunology/physiopathology
MH  - Coinfection
MH  - Disease Progression
MH  - Drug Resistance, Multiple, Bacterial/*immunology
MH  - Female
MH  - Host-Pathogen Interactions
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/chemically 
      induced/*immunology/physiopathology
MH  - Immunity, Cellular
MH  - Male
MH  - Mycobacterium tuberculosis/*pathogenicity
MH  - Tuberculosis/drug therapy/*immunology/physiopathology
EDAT- 2012/07/17 06:00
MHDA- 2013/04/02 06:00
CRDT- 2012/07/17 06:00
PHST- 2011/07/18 00:00 [received]
PHST- 2012/03/04 00:00 [revised]
PHST- 2012/05/11 00:00 [accepted]
PHST- 2012/07/17 06:00 [entrez]
PHST- 2012/07/17 06:00 [pubmed]
PHST- 2013/04/02 06:00 [medline]
AID - S1472-9792(12)00085-6 [pii]
AID - 10.1016/j.tube.2012.05.006 [doi]
PST - ppublish
SO  - Tuberculosis (Edinb). 2012 Sep;92(5):384-7. doi: 10.1016/j.tube.2012.05.006. Epub 
      2012 Jul 12.