PMID- 22795954
OWN - NLM
STAT- MEDLINE
DCOM- 20130201
LR  - 20231213
IS  - 1096-0023 (Electronic)
IS  - 1043-4666 (Linking)
VI  - 60
IP  - 1
DP  - 2012 Oct
TI  - Transcriptional regulation of IL-17A and other inflammatory markers during the 
      development of soybean meal-induced enteropathy in the distal intestine of 
      Atlantic salmon (Salmo salar L.).
PG  - 186-96
LID - 10.1016/j.cyto.2012.05.027 [doi]
AB  - Progression of soybean meal (SBM)-induced enteropathy in Atlantic salmon (Salmo 
      salar L.) distal intestine (DI) was studied to investigate pathophysiological 
      mechanisms and immune responses. Seawater-adapted salmon were fed an extracted 
      SBM-containing diet (200 g kg(-1)) from day 1-21 and compared with fish fed a 
      fishmeal-based diet (day 0). Histological evaluation of the DI revealed signs of 
      inflammation from day 5, which progressively increased in severity and affected 
      more fish with increasing SBM exposure time. The expression profiles of 16 genes 
      were analyzed by quantitative PCR. The pro-inflammatory cytokines interleukin 17A 
      (IL-17A), IL-1beta, interferon alpha (IFNalpha) and IFNgamma, as well as IL-17A receptor, T-cell 
      receptor gamma (TCRgamma), cluster of differentiation 4alpha (CD4alpha), CD8beta, transforming 
      growth factor beta (TGFbeta), trypsin, protease-activated receptor 2 (PAR2) and myeloid 
      differentiation primary response gene 88 (MyD88) were significantly up-regulated 
      during early and/or late inflammation stages, whereas interferon-gamma-inducible 
      lysosomal thiol reductase (GILT) was downregulated. Up-regulation of TCRgamma from 
      day seven suggests proliferation of intraepithelial gammadelta T cells. IL-17A, 
      up-regulated by 218-fold during early inflammation, indicates involvement of T 
      helper 17 cells in the pathogenesis of the SBM-induced inflammatory response.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Marjara, Inderjit S
AU  - Marjara IS
AD  - Aquaculture Protein Centre (a Centre of Excellence), Department of Basic Sciences 
      and Aquatic Medicine, Norwegian School of Veterinary Science, P.O. Box 8146 Dep., 
      0033 Oslo, Norway. Inderjit.mercy@gmail.com
FAU - Chikwati, Elvis M
AU  - Chikwati EM
FAU - Valen, Elin C
AU  - Valen EC
FAU - Krogdahl, Ashild
AU  - Krogdahl A
FAU - Bakke, Anne Marie
AU  - Bakke AM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120712
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Cytokines)
RN  - 0 (Fish Proteins)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-17)
RN  - 0 (Myeloid Differentiation Factor 88)
RN  - 0 (Receptor, PAR-2)
RN  - 0 (Receptors, Antigen, T-Cell, gamma-delta)
RN  - 0 (Receptors, Interleukin-17)
RN  - EC 1.8.- (Oxidoreductases Acting on Sulfur Group Donors)
SB  - IM
MH  - Animal Feed/adverse effects
MH  - Animals
MH  - Cytokines/genetics
MH  - Down-Regulation
MH  - Enteritis/etiology/*genetics
MH  - Fish Diseases/etiology/*genetics
MH  - Fish Proteins/*genetics
MH  - Gene Expression Profiling
MH  - Inflammation Mediators/*metabolism
MH  - Interleukin-17/*genetics
MH  - Myeloid Differentiation Factor 88/genetics
MH  - Oxidoreductases Acting on Sulfur Group Donors/genetics
MH  - Receptor, PAR-2
MH  - Receptors, Antigen, T-Cell, gamma-delta/genetics
MH  - Receptors, Interleukin-17/genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Salmo salar/*genetics
MH  - Glycine max/adverse effects
MH  - Time Factors
MH  - Transcription, Genetic
MH  - Up-Regulation
EDAT- 2012/07/17 06:00
MHDA- 2013/02/05 06:00
CRDT- 2012/07/17 06:00
PHST- 2011/12/13 00:00 [received]
PHST- 2012/04/18 00:00 [revised]
PHST- 2012/05/26 00:00 [accepted]
PHST- 2012/07/17 06:00 [entrez]
PHST- 2012/07/17 06:00 [pubmed]
PHST- 2013/02/05 06:00 [medline]
AID - S1043-4666(12)00226-8 [pii]
AID - 10.1016/j.cyto.2012.05.027 [doi]
PST - ppublish
SO  - Cytokine. 2012 Oct;60(1):186-96. doi: 10.1016/j.cyto.2012.05.027. Epub 2012 Jul 
      12.