PMID- 22795961
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20220311
IS  - 1943-7811 (Electronic)
IS  - 1525-1578 (Print)
IS  - 1525-1578 (Linking)
VI  - 14
IP  - 5
DP  - 2012 Sep
TI  - What is new in clinical microbiology-microbial identification by MALDI-TOF mass 
      spectrometry: a paper from the 2011 William Beaumont Hospital Symposium on 
      molecular pathology.
PG  - 419-23
LID - 10.1016/j.jmoldx.2012.03.007 [doi]
AB  - Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass 
      spectrometry (MS) offers the possibility of accurate, rapid, inexpensive 
      identification of bacteria, fungi, and mycobacteria isolated in clinical 
      microbiology laboratories. The procedures for preanalytic processing of organisms 
      and analysis by MALDI-TOF MS are technically simple and reproducible, and 
      commercial databases and interpretive algorithms are available for the 
      identification of a wide spectrum of clinically significant organisms. Although 
      only limited work has been reported on the use of this technique to identify 
      molds, perform strain typing, or determine antibiotic susceptibility results, 
      these are fruitful areas of promising research. As experience is gained with 
      MALDI-TOF MS, it is expected that the databases will be expanded to resolve many 
      of the current inadequate identifications (eg, no identification, genus-level 
      identification) and algorithms for potential misidentification will be developed. 
      The current lack of Food and Drug Administration approval of any MALDI-TOF MS 
      system for organism identification limits widespread use in the United States.
CI  - Copyright (c) 2012 American Society for Investigative Pathology and the Association 
      for Molecular Pathology. Published by Elsevier Inc. All rights reserved.
FAU - Murray, Patrick R
AU  - Murray PR
AD  - Scientific Affairs, Becton Dickinson Diagnostic Systems, Sparks, Maryland 21152, 
      USA. Patrick_murray@bd.com
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Review
DEP - 20120711
PL  - United States
TA  - J Mol Diagn
JT  - The Journal of molecular diagnostics : JMD
JID - 100893612
SB  - IM
MH  - Bacteria/*isolation & purification
MH  - Bacteriological Techniques
MH  - Fungi/*isolation & purification
MH  - Humans
MH  - Microbial Sensitivity Tests
MH  - Mycology/methods
MH  - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/*methods
PMC - PMC3427873
EDAT- 2012/07/17 06:00
MHDA- 2013/01/04 06:00
PMCR- 2013/09/01
CRDT- 2012/07/17 06:00
PHST- 2012/01/26 00:00 [received]
PHST- 2012/02/23 00:00 [revised]
PHST- 2012/03/06 00:00 [accepted]
PHST- 2012/07/17 06:00 [entrez]
PHST- 2012/07/17 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
PHST- 2013/09/01 00:00 [pmc-release]
AID - S1525-1578(12)00142-0 [pii]
AID - JMDI166 [pii]
AID - 10.1016/j.jmoldx.2012.03.007 [doi]
PST - ppublish
SO  - J Mol Diagn. 2012 Sep;14(5):419-23. doi: 10.1016/j.jmoldx.2012.03.007. Epub 2012 
      Jul 11.